- Synthetic method of imidazopyridine compounds
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The invention provides a novel method for synthesizing imidazopyridine compounds. According to the invention, aminopyridine compounds and sulfur ylide are used as original reaction substrates, iron phthalocyanine (FeIIPc) is used as a catalyst, and a series of the imidazopyridine compounds are obtained under the condition that the advantages of mildness, greenness, high efficiency, wide substrateuniversality and the like are achieved.
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Paragraph 0056; 0065-0068
(2021/03/24)
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- Green procedure for highly efficient, rapid synthesis of imidazo[1,2-a]pyridine and its late stage functionalization
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We unfold a rapid synthetic protocol for the preparation of imidazo[1,2-a]pyridine in cyclohexane. This methodology includes several advantages like shorter reaction time, catalyst free, broader substrate scope, and good yields of the desired products. La
- Ghosh, Prasanjit,Ganguly, Bhaskar,Kar, Barnali,Dwivedi, Seema,Das, Sajal
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p. 1076 - 1084
(2018/04/02)
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- Method for synthesizing novel imidazole pyranone compounds containing chalcogens
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The invention discloses a method for synthesizing novel imidazole pyranone compounds containing chalcogens. The method comprises the steps as follows: firstly, 4-hydroxycoumarin compounds and triflicanhydride react, and 4-triflate-based coumarins are gene
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Paragraph 0080; 0082
(2018/04/02)
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- Method for synthesizing 2-arylimidazo[1, 2-a]pyridine compounds from ethylbenzene compounds
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The invention discloses a method for synthesizing 2-arylimidazo[1, 2-a]pyridine compounds from ethylbenzene compounds and belongs to the field of 2-arylimidazo[1, 2-a]pyridine derivative synthesis. The method comprises that an ethylbenzene compound, a phase transfer catalyst, N-bromosuccinimide NBS and AIBN are added into water, the solution undergoes a reaction at 60 DEG C, an inorganic base andan alpha-aminopyridine compound are added into the reaction product, and the mixture undergoes a reaction at 80 DEG C to produce the 2-arylimidazo[1, 2-a]pyridine compound. The method creatively utilizes the ethylbenzene compound to synthesize the 2-arylimidazo[1, 2-a]pyridine compound. Compared with the 2-bromoacetophenone commonly used as a 2-arylimidazo[1, 2-a]pyridine compound synthesis raw material in the industry, the ethylbenzene compound is cheaper and more easily available.
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Paragraph 0095; 0096; 0097; 0098
(2018/11/27)
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- Method for synthesizing 2-arylimidazo[1, 2-a]pyridine compound
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The invention discloses a method for synthesizing a 2-arylimidazo[1, 2-a]pyridine compound and belongs to the technical field of organic synthesis. The method comprises that an ethylbenzene compound,dibromohydantoin DBH and t-butyl hydroperoxide TBHP are added into water and undergo a reaction at 60 DEG C, an inorganic base and an alpha-aminopyridine compound are added into the reaction product and the mixture undergoes a reaction at 80 DEG C to produce a desired product 2-arylimidazo[1, 2-a]pyridine compound. The 2-arylimidazo[1, 2-a]pyridine compound is synthesized from the ethylbenzene compound which is cheaper and more readily available than the 2-arylimidazo[1, 2-a]pyridine compounds such as 2-bromoacetophenone commonly used in the industry.
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Paragraph 0093; 0094; 0095; 0096
(2018/11/27)
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- Copper-Catalyzed Aerobic Oxidative Cyclization of Ketoxime Acetates with Pyridines for the Synthesis of Imidazo[1,2-a]pyridines
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A copper(I)-catalyzed aerobic oxidative coupling of ketoxime acetates with simple pyridines for the synthesis of imidazo[1,2-a]pyridines has been developed. This reaction tolerates a wide range of functional groups and it affords a series of valuable imidazo[1,2-a]pyridines in high yields under mild conditions.
- Ren, Zhi-Hui,Zhao, Mi-Na,Yi, Yukun,Wang, Yao-Yu,Guan, Zheng-Hui
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p. 1920 - 1926
(2016/06/15)
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- Graphene oxide (GO)-catalyzed multi-component reactions: Green synthesis of library of pharmacophore 3-sulfenylimidazo[1,2-a]pyridines
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The green carbocatalyst graphene oxide (GO) has been successfully utilized for selective and expedient synthesis of biologically important motifs imidazo[1,2-a]pyridines, and 3-sulfenylimidazo[1,2-a]pyridines via one-pot multi-component reactions (MCR). D
- Kundu, Samir,Basu, Basudeb
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p. 50178 - 50185
(2015/06/25)
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- A highly active and easily recoverable chitosan@copper catalyst for the C-S coupling and its application in the synthesis of zolimidine
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Aryl sulfones were synthesized using a highly active and easily recoverable heterogeneous Cu catalyst which was prepared by simply stirring an aqueous suspension of chitosan in water with copper salts. The chitosan@copper catalyst catalyzed the coupling reactions of aryl halides with sodium sulfinates to readily give the corresponding sulfones in good to excellent yields. The highly active catalyst can be reused many times without losing its catalytic activity. In addition, by using this protocol, the marketed drug zolimidine (antiulcer) could be synthesized easily. This journal is the Partner Organisations 2014.
- Shen, Chao,Xu, Jun,Yu, Wenbo,Zhang, Pengfei
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supporting information
p. 3007 - 3012
(2014/06/10)
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- CuI-catalyzed aerobic oxidative α-aminaton cyclization of ketones to access aryl or alkenyl-substituted imidazoheterocycles
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CuI-catalyzed aerobic oxidative synthesis of imidazoheterocycles has been achieved. Four hydrogen atoms were removed in one step. This protocol was compatible with a broad range of functional groups, and it has been also successfully extended to unsaturated ketones, bringing about the formation of alkenyl-substituted imidazoheterocycles, which were difficult to prepare by previous means. Preliminary mechanistic studies indicated that this reaction was most likely to proceed through a catalytic Ortoleva-King reaction. By using this method, the marketed drug Zolimidine could be prepared with 90% yield on a gram scale from commercially available materials.
- Zhang, Yuhong,Zhang, Yuanfei,Chen, Zhengkai,Wu, Wenliang,Su, Weiping
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supporting information
p. 12494 - 12504
(2014/01/17)
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- NITROGENOUS HETEROCYCLIC DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT EMPLOYING THE SAME
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A specific derivative of heterocyclic compound having nitrogen atom and an organic electroluminescence device comprising the compound. An organic electroluminescence device comprising at least one of organic compound layers including a light emitting layer sandwiched between an anode and a cathode, wherein said at least one of the organic compound layers comprises the derivative of the heterocyclic compound having nitrogen atom as a sole component or as mixed component. The organic electroluminescence device achieves elevation of luminance and excellent efficiency of light emission, and also achieves long lifetime by an improvement of an electrode adhesion.
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Page/Page column 83
(2008/06/13)
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- Bis-cationic heteroaromatics as macrofilaricides: Synthesis of Bis- amidine and bis-guanylhydrazone derivatives of substituted imidazol[1,2- a]pyridines
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A series of guanylhydrazone, amidine, and hydrazone derivatives of 2- phenylimidazo[1,2-a]-pyridine have been prepared and evaluated for macrofilarial activity against Acanthocheilonema viteae and Brugia pahangi in jirds. Compounds with 4',6-bis-substitut
- Sundberg, Richard J.,Biswas, Sujay,Murthi, Krishna Kumar,Rowe, Donna,McCall, John W.,Dzimianski, Michael T.
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p. 4317 - 4328
(2007/10/03)
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