cas 21500-98-1, Tenocyclidine | Articles data

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Preparation of tertiary alkyl carbinamines, propargylamines, and α-heteroarylamines by ketone-based aminoalkylation
(Chemical Equation Presented). Ketones 6a-i were converted into their benzotriazolylamine adducts 8a-i either directly from the corresponding ketone 6a or via enamines 7b-i. Adducts 8a-i on treatment with Grignard reagents, lithium phenylacetylide, or heteroaryllithiums gave tertiary alkyl carbinamines 9a-h (47-61%), propargylamines 10a-i (30-98%), and α-heteroarylamines 11a-k (44-85%), respectively.
Katritzky, Alan R.,Yang, Hongfang,Singh, Sandeep K.
p. 286 - 290
(2007/10/03)

SUBSTITUTED 1-(2-THIENYL)CYCLOHEXYLAMINES AND RELATED COMPOUNDS AS POTENTIAL NMDA ANTAGONISTS
Reactions of bisulfite addition compounds prepared in situ from cyclohexanone or 3,4,5,6-tetrahydro-2H-thiopyran-3-one with potassium cyanide and corresponding amines resulted with high yields in amino nitriles type of V and VI.These compounds were subjected to reactions with 2-thienylmagnesium bromide and in the case of the amino nitriles Vc and Vf with 5-bromo-2-thienylmagnesium bromide.Only in the case of compound Vf, a by-product X was isolated in addition to the desired 1-piperidine (VIIf).Compound VIIf was used for the synthesis of the carboxylic acid XI.The compounds prepared were tested by some methods of biochemical and behavioural pharmacology.
Sindelar, Karel,Dobrovsky, Karel,Krejci, Ivan,Polivka, Zdenek
p. 894 - 902
(2007/10/02)