Ethyl(methyl)dioxirane as an efficient reagent for the oxidation of nucleoside phosphites into phosphates under nonbasic anhydrous conditions.
A convenient method for the oxidation of nucleoside phosphites into phosphates under nonbasic and nonaqueous conditions using commercially available ethyl(methyl)dioxirane has been developed. This oxidation is effective with both N-protected and N-unprote
Kataoka,Hattori,Okino,Hyodo,Asano,Kawai,Hayakawa
p. 815 - 818
(2007/10/03)
Evidence supporting the activity of 2'-C-cyano-2'-deoxy-1-β-D-arabino- pentafuranosylcytosine as a terminatorin enzymatic DNA-chain elongation
To investigate the stability of 2'-C-cyano-2'-deoxy- 1-β-D-arabino- pentafuranosylcytosine 3'phosphoric acid, its thymidine ester was prepared via the phosphoramidite method using allyl protection for the phosphate function. This ester is stable under aci