- Synthesis and pharmacological characterization of 4-substituted-2- aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: Identification of new potent and selective metabotropic glutamate 2/3 receptor agonists
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As part of our ongoing interest in identifying novel agonists acting at metabotropic glutamate (mGlu) 2/3 receptors, we have explored the effect of structural modifications of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6- dicarboxylate (LY354740), a potent
- Monn, James A.,Valli, Matthew J.,Massey, Steven M.,Hao, Junliang,Reinhard, Matthew R.,Bures, Mark G.,Heinz, Beverly A.,Wang, Xushan,Carter, Joan H.,Getman, Brian G.,Stephenson, Gregory A.,Herin, Marc,Catlow, John T.,Swanson, Steven,Johnson, Bryan G.,McKinzie, David L.,Henry, Steven S.
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p. 4442 - 4455
(2013/07/19)
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- EXCITATORY AMINOACID RECEPTOR MODULATORS
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Compounds of the formula STR1 in which R 1 and R 2 are as defined in the specification, and non-toxic metabolically labile ester and amides thereof are useful as modulators of metabotropic glutamate receptor function.
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