216433-58-8

Basic information

• Product Name: 2,4,6-TRIMETHOXY-BETA-NITROSTYRENE, >95%
• Synonyms: 2,4,6-TRIMETHOXY-BETA-NITROSTYRENE, >95%;(E)-1,3,5-trimethoxy-2-(2-nitrovinyl)benzene
• CAS NO: 216433-58-8
• Molecular Formula: C11H13NO7
• Molecular Weight: 239.22
• Mol File: 216433-58-8.mol

Chemical Properties

• Boiling Point: 405.726°C at 760 mmHg
• Flash Point: 186.617°C
• Appearance: /
• Density: 1.204g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: 2,4,6-TRIMETHOXY-BETA-NITROSTYRENE, >95%(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-TRIMETHOXY-BETA-NITROSTYRENE, >95%(216433-58-8)
• EPA Substance Registry System: 2,4,6-TRIMETHOXY-BETA-NITROSTYRENE, >95%(216433-58-8)

Safety Data

• Hazardous Substances Data: 216433-58-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,4,6-Trimethoxy-beta-nitrostyrene, >95% is used as a key intermediate for the synthesis of complex organic molecules. Its unique structure allows for a wide range of reactions, making it a valuable building block in the creation of new compounds.
Used in Pharmaceutical Production:
2,4,6-Trimethoxy-beta-nitrostyrene, >95% serves as a precursor in the production of various pharmaceuticals and fine chemicals. Its presence in the synthesis process contributes to the development of new drugs and therapeutic agents.
Used in Research and Development:
2,4,6-Trimethoxy-beta-nitrostyrene, >95% is utilized in the research and development of new materials and compounds. Its versatile reactivity and properties make it an essential tool for scientists and researchers working on innovative projects.
Used in Material Science:
2,4,6-Trimethoxy-beta-nitrostyrene, >95% is used as a component in the development of new materials, such as polymers and composites. Its unique chemical structure contributes to the creation of materials with improved properties and performance.
Safety Precautions:
It is crucial to handle 2,4,6-Trimethoxy-beta-nitrostyrene, >95% with caution and follow proper safety measures due to its potentially hazardous nature. This includes using appropriate personal protective equipment, working in a well-ventilated area, and following established safety protocols.

InChI:InChI=1/C11H13NO5/c1-15-8-6-10(16-2)9(4-5-12(13)14)11(7-8)17-3/h4-7H,1-3H3

Upstream product

• 621-23-8 1,2,3-trimethoxybenzene 
• 75-52-5 nitromethane 
• 830-79-5 2,4,6-trimethoxybenzaldehyde 
• 79-24-3 Nitroethane 
• 570-02-5 2,4,6-trimethoxybenzoic acid 

Relevant articles and documents

Pd-catalyzed multidehydrogenative cross-coupling between (Hetero)arenes and nitroethane to construct β-aryl nitroethylenes

The Pd-catalyzed multidehydrogenative cross-coupling reactions of arenes with nitroethane are described. The established methods afford β-aryl nitroethylenes that are an important class of synthetic intermediates and biologically active compounds in an atom- and step-economical fashion. The reactions were applicable to substituted benzenes and a variety of heterocycles such as benzothiophenes, benzofurans, and indoles. Mechanistic experiments indicated that β-nitroethylbenzene might be the intermediate in this transformation.

CYTOKINE INHIBITORS

The present invention provides compounds represented by general formula (I): wherein, R1; R2, R3, L and T are as defined in the specification, in all their stereoisomeric and tautomeric forms and mixtures thereof in all ratios, and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, and prodrugs thereof. The invention also relates to processes for the manufacture of compounds of formula (I) and pharmaceutical compositions containing them. The compounds and the pharmaceutical compositions of the present invention are useful in the treatment of a condition or disorder mediated by one or more cytokines selected from Tumor Necrosis Factor-alpha (TNF-oc) and interleukins such as IL-1, IL-6, and IL-8. The present invention further provides a method of treatment of inflammatory disorders by administering a therapeutically effective amount of the said compound of formula (I) or its pharmaceutical composition, to a mammal in need thereof.

Pd-catalyzed cross-coupling of carboxylic acids with nitroethane via combination of decarboxylation and dehydrogenation

An unexpected coupling reaction of arene carboxylic acid with nitroethane via a combination of decarboxylation and dehydrogenation is described. The method provides exclusively (E)-β-nitrostyrenes. The Royal Society of Chemistry 2010.

E-Combretastatin and E-resveratrol structural modifications: Antimicrobial and cancer cell growth inhibitory β-E-nitrostyrenes

As part of a broad-based SAR investigation of E-resveratrol (strong sirtuin activator and antineoplastic) and the anticancer vascular-targeting combretastatin-type stilbenes, a series of twenty-three β-E-nitrostyrenes was synthesized in order to evaluate potential antineoplastic, antitubulin, and antimicrobial activities. The β-E-nitrostyrenes evaluated ranged from monosubstituted phenols to trimethoxy and 3-methoxy-4,5-methylenedioxy derivatives. Two of the β-nitrostyrenes were synthesized as water-soluble sodium phosphate derivatives (4t, 4v). All except four (4r, 4s, 4t, 4u) of the series significantly inhibited a minipanel of human cancer cell lines. All but eight led to an IC50 of 10 μM for inhibition of tubulin polymerization, and all except three (4l, 4t, 4v) displayed antimicrobial activity.

Investigation of pore-size effects on base catalysis using amino-functionalized monodispersed mesoporous silica spheres as a model catalyst

The effects of pore size on base catalysis have been studied using amino-functionalized monodispersed mesoporous silica spheres (NH2-MMSS). By changing the surfactant that is used for the template and also the synthetic conditions, NH2/su

One-pot synthesis of trans-β-alkylstyrenes

One-pot synthesis of (E)-alkenes 5 from the reactions of aldehyde 1 and nitromethane 2 in the acetic acid solution and then with triethylborane 4 in the biphase of diethyl ether and aqueous solution in the presence of oxygen in air was reported. Various (E)-alkenes 7 could also be prepared when different kinds of secondary or tertiary alkyl iodides 6 were used under similar conditions.

Gel entrapped base catalysed (GEBC) Henry reaction: Synthesis of conjugated nitroalkenes

A new, simple and practical procedure for direct transformation of aldehydes or ketones and nitromethane into conjugated nitroalkenes by using novel gel entrapped base catalyst (GEBC) has been described.

The ultrasound promoted Knoevenagel condensation of aromatic aldehydes

Application of ultrasound has been found to greatly assist the Knoevenagel aldol condensation reaction of activated methylenes with aromatic aldehydes under mild conditions. The outcome of the ultrasound-promoted reaction depends upon the electronic nature of the aromatic aldehyde, the solvent employed and the addition of acids, bases or ammonium salts.