216443-78-6

Basic information

• Product Name: 3-(3-METHYLPHENYL)BENZALDEHYDE
• Synonyms: 3'-METHYLBIPHENYL-3-CARBALDEHYDE;3'-METHYL-BIPHENYL-3-CARBOXALDEHYDE;3'-METHYL[1,1'-BIPHENYL]-3-CARBALDEHYDE;3'-METHYL [1,1'-BIPHENYL]-3-CARBOXALDEHYDE;AKOS BAR-0067;3-(3-METHYLPHENYL)BENZALDEHYDE;3-(3-Tolyl)benzaldehyde
• CAS NO: 216443-78-6
• Molecular Formula: C₁₄H₁₂O
• Molecular Weight: 196.24
• Product Categories: pharmacetical
• Mol File: 216443-78-6.mol

Chemical Properties

• Boiling Point: 337.3 °C at 760 mmHg
• Flash Point: 183.6 °C
• Appearance: /
• Density: 1.074g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-(3-METHYLPHENYL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-METHYLPHENYL)BENZALDEHYDE(216443-78-6)
• EPA Substance Registry System: 3-(3-METHYLPHENYL)BENZALDEHYDE(216443-78-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 216443-78-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
3-(3-METHYLPHENYL)BENZALDEHYDE is used as a reagent for the synthesis of various organic compounds, particularly benzoxazoles derivatives and substituted nitrobenzaldehydes. Its unique structure allows it to participate in a range of chemical reactions, such as condensation, reduction, and oxidation, which are essential for creating complex molecular structures.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-(3-METHYLPHENYL)BENZALDEHYDE is utilized as an intermediate in the synthesis of drugs with potential therapeutic applications. Its ability to form diverse chemical structures makes it a valuable component in the development of new medications.
Used in Chemical Research:
3-(3-METHYLPHENYL)BENZALDEHYDE is also employed in chemical research as a model compound for studying various reaction mechanisms and exploring new synthetic pathways. Its reactivity and structural features provide valuable insights into the behavior of similar compounds and contribute to the advancement of organic chemistry.

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 17933-03-8 m-tolylboronic acid 
• 108-41-8 1-chloro-3-methylbenzene 
• 587-04-2 m-Chlorobenzaldehyde 

Relevant articles and documents

Scope of the two-step, one-pot palladium-catalyzed borylation/Suzuki cross-coupling reaction utilizing bis-boronic acid

The use of bis-boronic acid for the direct synthesis of boronic acids has greatly facilitated the two-step, one-pot borylation/Suzuki cross-coupling reaction between aryl and heteroaryl halides. With use of Buchwald's second-generation XPhos preformed catalyst, high yields of cross-coupled products were obtained for most substrates. The method also allows an efficient two-step, one-pot synthesis, providing access to three distinct cross-coupled products after column chromatography. The method also provides a rapid and convenient route to teraryl compounds.

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