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2165-19-7

Articles about 2165-19-7Total 3 be found

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N-Hydroxyl derivatives of guanidine based drugs as enzymatic NO donors
Recent research suggests that NO may play a role in the physiological effects of some guanidine-containing drugs. In this report, three guanidine-containing drugs (guanadrel, guanoxan, and guanethidine) together with their N-hydroxyl derivatives were synthesized and their NO-releasing abilities catalyzed by nitric oxide synthases (NOSs) and horseradish peroxidase were evaluated. The guanidine containing compounds could not release NO in the presence of NOS or peroxidase. The corresponding N-hydroxyl compounds exhibited weak NO-releasing ability under the catalyzed of NOS and good NO-releasing ability under the oxidation by horseradish peroxidase in the presence of H2O2. These compounds also displayed vasodilatory activity. Elsevier Science Ltd. All rights reserved.
Xian, Ming,Li, Xiaopeng,Tang, Xiaoping,Chen, Xinchao,Zheng, Zhongling,Galligan, James J,Kreulen, David L,Wang, Peng G
p. 2377 - 2380
(2007/10/03)

Adrenergic neurone blocking agents derived from 1,4-benzodioxan.
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Augtein,Green,Monro,Potter,Worthing,Wrigley
p. 446 - 456
(2007/10/04)

THE SYNTHESIS AND PHARMACOLOGY OF SOME SUBSTITUTED 1,3-BENZODIOXOLES
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BAINES,COBB,EDEN,FIELDEN,GARDNER,ROE,TERTIUK,WILLEY
p. 81 - 90
(2007/10/04)

More Articles about upstream products of 2165-19-7

Chemical Properties

Melting Point: 164-165°
Boiling Point: 389.9°Cat760mmHg
Flash Point:189.6°C
Density: 1.4g/cm³
Vapor Pressure: 2.75E-06mmHg at 25°C
PKA: pKa 12.3 (Uncertain)
PSA: 80.36000
LogP: 1.50040

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