216529-53-2

Basic information

• Product Name: 2-PYRIDIN-4-YL-1-M-TOLYL-ETHANONE
• Synonyms: 2-PYRIDIN-4-YL-1-M-TOLYL-ETHANONE;Ethanone, 1-(3-Methylphenyl)-2-(4-pyridinyl)-;1-(3-Methylphenyl)-2-(4-pyridinyl)-ethanone
• CAS NO: 216529-53-2
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.26
• Mol File: 216529-53-2.mol

Chemical Properties

• Melting Point: 115-116 °C(Solv: ethyl acetate (141-78-6); isopropyl ether (108-20-3))
• Boiling Point: 370.8 °C at 760 mmHg
• Flash Point: 185.6 °C
• Appearance: /
• Density: 1.105 g/cm³
• PKA: 5.22±0.10(Predicted)
• CAS DataBase Reference: 2-PYRIDIN-4-YL-1-M-TOLYL-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PYRIDIN-4-YL-1-M-TOLYL-ETHANONE(216529-53-2)
• EPA Substance Registry System: 2-PYRIDIN-4-YL-1-M-TOLYL-ETHANONE(216529-53-2)

Safety Data

• Hazardous Substances Data: 216529-53-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyridin-4-yl-1-m-tolyl-ethanone is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure and reactivity allow it to be incorporated into the development of new drugs, potentially leading to innovative treatments for various medical conditions.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Pyridin-4-yl-1-m-tolyl-ethanone serves as a key intermediate in the production of pesticides and other crop protection agents. Its potential biological activities and ability to participate in chemical reactions make it a valuable component in the creation of effective and targeted agrochemicals.
Used in Research and Development:
2-Pyridin-4-yl-1-m-tolyl-ethanone is utilized in research and development efforts to explore its potential applications and properties. Further studies are needed to fully understand its biological activities and to harness its potential in the development of new drugs and pesticides.

Upstream product

• 108-89-4 picoline 
• 21384-43-0 1-(3-methylbenzoyl)-2-methylaziridine 
• 1711-06-4 3-Methylbenzoyl chloride 
• 99-36-5 1-methoxycarbonyl-3-methylbenzene 
• 6576-05-2 1-(4-fluorophenyl)-2-(4-pyridyl)ethanone 
• 26954-25-6 (4-pyridylmethyl)lithium 
• 135754-82-4 3-methyl-N-methoxy-N-methylbenzamide 

Downstream Products

• 271577-17-4 1-(3-tolyl)-2-(1,3-dithietan-2-ylidene)-2-(pyridin-4-yl)ethanone 
• 216504-41-5 4-[5-(3-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]pyridine 
• 325769-18-4 methyl 4-[4-(3-methylphenyl)-5-(4-pyridyl)-1,3-thiazol-2-yl]benzoate 
• 325769-12-8 N-methyl-[4-(3-methylphenyl)-5-(4-pyridyl)-1,3-thiazol-2-yl]amine 
• 224038-59-9 [4-(3-methylphenyl)-5-(4-pyridyl)-1,3-thiazol-2-yl]amine 
• 325769-02-6 methyl 4-[4-(3-methylphenyl)-5-(pyridin-4-yl)-1,3-thiazol-2-yl]phenyl sulfide 
• 365430-22-4 4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridine 1-oxide 
• 325769-17-3 2-ethyl-4-(3-methylphenyl)-5-(4-pyridyl)-1,3-thiazole 

Relevant articles and documents

Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase

Starting from an initial HTS screening lead, a novel series of C(5)-substituted diaryl pyrazoles were developed that showed potent inhibition of p38α kinase. Key to this outcome was the switch from a pyridyl to pyrimidine at the C(4)-position leading to analogs that were potent in human whole blood based cell assay as well as in a number of animal efficacy models for rheumatoid arthritis. Ultimately, we identified a clinical candidate from this substrate; SD-0006.

Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as selective adenosine A3 antagonists

To investigate the potency of an adenosine A3 receptor (A 3AR) antagonist as an anti-asthmatic drug, a novel series of 4-phenyl-5-pyridyl-1,3-thiazole derivatives was synthesized and evaluated in human adenosine A1, A

THERAPEUTIC FLUOROETHYL UREAS

Compounds of the formula or a pharmaceutically acceptable salt thereof or a tautomer thereof, wherein A and B are as described herein, are useful for treating conditions afflicting mammals.

Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as p38 MAP kinase inhibitors

A novel series of 4-phenyl-5-pyridyl-1,3-thiazole analogues possessing potent in vitro inhibitory activity against p38 mitogen-activated protein kinase and the release of tumor necrosis factor-α (TNF-α) from human monocytic THP-1 cells stimulated by lipopolysaccharide has been identified. Subsequent structure-activity relationship (SAR) studies and optimization for absorption, distribution, metabolism, and elimination (ADME) profiles led to the identification of compounds 7g and 10b as orally active lead candidates that block the in vivo production of proinflammatory cytokine (TNF-α). In pharmacokinetic studies, compound 10b showed good oral administration in mice and demonstrated significant in vivo anti-inflammatory activity in an anti-collagen monoclonal antibody-induced arthritis mouse model (minimum effective dose (MED)=30 mg/kg). Further elucidation of this class of compounds may provide novel anti-inflammatory agents, such as anti-rheumatoid arthritis drugs.

Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: Discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent

The p38 mitogen-activated protein (MAP) kinase has been implicated in the proinflammatory cytokine signal pathway, and its inhibitors are potentially useful for the treatment of chronic inflammatory diseases such as rheumatoid arthritis (RA) and inflammat

Substituted pyrazoles as p38 kinase inhibitors

A class of pyrazole derivatives is described for use in treating p38 kinase mediated disorders. Compounds of particular interest are defined by Formula (IA), wherein R1, R2, R3 and R4 are as described in the spe

Process for making substituted pyrazoles

This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.

Adenosine A3 receptor antagonists

A pharmaceutical composition for antagonizing adenosine at adenosine A3receptors which comprises a 1,3-azole compound substituted on the 4- or 5-position, or both, by a pyridyl which may be substituted is provided and can be used as a prophylactic and therapeutic agent for asthma, allergosis, inflammation, and so on.