Optimization of Alkylating Agent Prodrugs Derived from Phenol and Aniline Mustards: A New Clinical Candidate Prodrug (ZD2767) for Antibody-Directed Enzyme Prodrug Therapy (ADEPT)
Sixteen novel potential prodrugs derived from phenol or aniline mustards and their 16 corresponding drugs with ring substitution and/or different alkylating functionalities were designed.The 4-bis(2-bromoethyl)-(1a), 4-bis(2-iodoethyl)-(1b), and
Springer, Caroline J.,Dowell, Robert,Burke, Philip J.,Hadley, Elma,Davies, D. Huw,et al.
p. 5051 - 5065
(2007/10/03)
Synthesis and evaluation of esters of N,N-bis(2-chloroethyl)-p-aminophenol and N,N-bis(2-bromoethyl)-p-aminophenol as potential antitumor agents.
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Vickers,Hebborn,Moran,Triggle
p. 491 - 494
(2007/10/05)
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