- ETUDE D'UN SCHEMA DE SYNTHESE PEPTIDIQUE INTRAMOLECULAIRE A L'AIDE DE DERIVES DU PHOSPHORE TETRAEDRIQUE
-
A new scheme of repetitive and controlled peptide synthesis offers two advantages compared to the usual methods of synthesis: two steps only are used for the prolongation of a peptide chain with an amino-acid residue and the risk of racemisation is minimized.The two postulated steps are verified particularly by the rearrangement, in an alkaline alcoholic medium, of phosphordiamides 1 incorporating one amino-acid residue, leading to the formation of the peptide derivatives 6 and 8.The severe limitations of this method are discussed.
- Mulliez, M.
-
p. 2027 - 2041
(2007/10/02)
-
- Phosphorus-fluorine chemistry. XIII. The adduct of nitrosyl fluoride with phenyltetrafluorophosphorane. New fluorophosphates
-
Nitrosyl fluoride was found to react with phenyltetrafluorophosphorane to form a solid, thermally unstable 1:1 adduct. Evidence for the formulation of this adduct as a nitrosyl salt, NO+C6H5PF5-, based on various chemical reactions, is presented. The novel fluoroanions, R(Ar)PF5-, together with alkyl(aryl)dialkylaminotrifluorophosphoranes, R(Ar)PF3NR2, are also obtained in the form of stable dialkylammonium salts upon dialkylaminolysis of tetrafluorophosphoranes, R(Ar)PF4. The stereochemistry of the R(Ar)PF5- anions, and of the alkyl(aryl)dialkylaminotrifluorophosphoranes, based on n.m.r. spectroscopic studies, is discussed. In contrast to nitrosyl fluoride, nitryl fluoride reacted with phenyltetrafluorophosphorane with direct nitration of the aromatic ring.
- Schmutzler,Reddy
-
p. 191 - 197
(2007/10/04)
-