218160-26-0

Basic information

• Product Name: trans-N-Cyclopropyl-4-[4-(4-fluorophenyl)-2-[5-methyl-5-(4-morpholinylcarbonyl)-1,3-dioxan-2-yl]-1H-imidazol-5-yl]pyrimidin-2-amine
• Synonyms: RPR-203494; RPR203494
• CAS NO: 218160-26-0
• Molecular Formula: C₂₆H₂₉FN₆O₄
• Molecular Weight: 508.55723
• Mol File: 218160-26-0.mol

Chemical Properties

• CAS DataBase Reference: trans-N-Cyclopropyl-4-[4-(4-fluorophenyl)-2-[5-methyl-5-(4-morpholinylcarbonyl)-1,3-dioxan-2-yl]-1H-imidazol-5-yl]pyrimidin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: trans-N-Cyclopropyl-4-[4-(4-fluorophenyl)-2-[5-methyl-5-(4-morpholinylcarbonyl)-1,3-dioxan-2-yl]-1H-imidazol-5-yl]pyrimidin-2-amine(218160-26-0)
• EPA Substance Registry System: trans-N-Cyclopropyl-4-[4-(4-fluorophenyl)-2-[5-methyl-5-(4-morpholinylcarbonyl)-1,3-dioxan-2-yl]-1H-imidazol-5-yl]pyrimidin-2-amine(218160-26-0)

Safety Data

• Hazardous Substances Data: 218160-26-0(Hazardous Substances Data)

Upstream product

• 765-30-0 Cyclopropylamine 
• 35071-17-1 2-mercapto-6-methylpyrimidine 
• 439148-93-3 4-(4-fluoro-phenyl)-5-(2-methylsulfanyl-pyrimidin-4-yl)-1H-imidazole-2-carbaldehyde 
• 218162-50-6 2-thiomethylpyrimidin-4-yl-4-fluorophenylbenzil 
• 217661-99-9 1-(4-fluorophenyl)-2-(2-methylsulphanylpyrimidin-4-yl)-1-ethanone 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 14001-63-9 2-methylthio-4-methylpyrimidine 

Relevant articles and documents

Imidazolyl-cyclic acetals

Compounds of formula (I) are described in which R1is optionally substituted heteroaryl; R2is optionally substituted aryl or optionally substituted heteroaryl; R3is a group —L1—R7or —L2—Rsu

RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency

Following the discovery of RPR200765, a series of pyrimidine analogues have been prepared as backups. Amongst them, RPR203494 was identified with a better in vitro profile than RPR200765A.