- DIMETHYLFUMARATE AND PRODRUGS FOR TREATMENT OF MULTIPLE SCLEROSIS
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Methods and systems to evaluate prodrugs, drugs, or drug metabolites are provided.
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Page/Page column 201
(2016/01/16)
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- Silicon-Containing Fumaric Acid Esters
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The present invention is directed to silicon-containing fumaric acid esters of the Formulae I-IV. The silicon-containing fumaric acid esters of Formulae I-IV are useful in transplantation medicine and for the treatment of autoimmune diseases and autoimmune-related diseases. (I), (II), (III) and (IV)
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Paragraph 0123-0124
(2014/11/27)
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- PRODRUGS AND DRUGS
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Methods and systems to evaluate a prodrug are provided.
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Page/Page column 115; 116
(2014/12/12)
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- PHARMACEUTICAL COMPOSITIONS CONTAINING DIMETHYL FUMARATE
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Provided herein are compositions containing compounds, or pharmaceutically acceptable salts, that metabolize to monomethyl fumarate with certain pharmacokinetic parameters and methods for treating, prophylaxis, or amelioration of neurodegenerative diseases including multiple sclerosis using such compositions in a subject, wherein if the compositions contain dimethyl fumarate, the total amount of dimethyl fumarate in the compositions ranges from about 43% w/w to about 95% w/w.
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Paragraph 0260; 0261
(2013/08/28)
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- Preparation of acyloxysilanes
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Acyloxysilanes are prepared by the anhydrous reaction of stoichiometric amounts of a carboxylic acid with a mixture of a halosilane and a silazane in an aprotic solvent, such as diethyl ether, acetonitrile, tetrahydrofuran or toluene, in an inert gas atmosphere. In a preferred embodiment the silazane is prepared in situ by the reaction of the corresponding halosilane and ammonia. No catalyst is necessary and the reaction preferably is performed at a temperature of -5° C. to 45° C.
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- REACTIONS IN THE CHLOROSILANE-SILANOL-SILOXANE SYSTEM
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We obtained the first ?*-values and ES-values for siloxy groups by spectroscopic and kinetic methods.Detailed mechanistic investigations are performed on the hydrolysis of chlorosilanes, the cleavage of Si-O-Si bonds by HCl, and the substituent exchange reaction between silanols and chlorosilanes.
- Ruehlmann, K.
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p. 139 - 152
(2007/10/02)
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- ZUR SYNTHESE VON SILOXANEN. II, STERISCHE SUBSTITUENTENKONSTANTEN FUER SILOXYRESTE
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The acetolysis reactions of compounds of the type XSiMe2Cl (I) with acetic acid in the presence of acetic anhydride were studied kinetically by means of 1H NMR spectroscopy.We found these reactions exclusively influenced by steric effects (ρ=0).The steric susceptibility constant (δ) of the acetolysis reaction, using alkylchlorodimethylsilanes was found to be 1.3.In this investigation the Taft Es nvalues showed a better correlation than the Es(Si) values of Cartledge.From the rate constants of the acetolysis reactions with I (X=Cl, acetoxy or siloxy) we could then obtain for the first time Es values for Cl, acetoxy and a series of siloxy groups at silicon.
- Scheim, U.,Grosse-Ruyken, H.,Ruehlmann, K.,Porzel, A.
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