Synthesis of optically pure 2-azetidinones having N-dehydroamino acid side-chains
An efficient, three step synthesis of optically pure N-vinyl-2-azetidinones 1 starting from α- or β-amino ester imines has been developed. Stau?dinger reaction between amino ester derived imines and ketene precursors gave 2-azetidinones 2. Enolate formati
Alcaide, Benito,Polanco, Concepción,Sierra, Miguel A.