On the selective O-alkylation of ambident nucleophiles - The synthesis of thiohydroxamic acid O-esters by phase-transfer reactions
O-Alkylation of cyclic thiohydroxamic acids 1 and 3-5 has been studied with a view to developing an efficient method for the synthesis of N- (alkoxy)pyridine-2(1H)-thiones and N(alkoxy)thiazole-2(3H)-thiones. Four issues have been addressed and the follow