218456-68-9

Basic information

• Product Name: 2-[4-(tert-butyl)phenoxy]-5-nitropyridine
• Synonyms: 2-[4-(tert-butyl)phenoxy]-5-nitropyridine
• CAS NO: 218456-68-9
• Molecular Formula: C15H16N2O3
• Molecular Weight: 272.29914
• Mol File: 218456-68-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[4-(tert-butyl)phenoxy]-5-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(tert-butyl)phenoxy]-5-nitropyridine(218456-68-9)
• EPA Substance Registry System: 2-[4-(tert-butyl)phenoxy]-5-nitropyridine(218456-68-9)

Safety Data

• Hazardous Substances Data: 218456-68-9(Hazardous Substances Data)

Usage

Structure

Nitro group (NO₂) at the 5-position of a pyridine ring
Tert-butyl-substituted phenoxy group (C₄H₉) at the 2-position

Functionality

Nitro group provides reactivity for further chemical modification
Tert-butyl group offers steric hindrance and increased stability

Application

Used as a building block in the synthesis of pharmaceutical compounds and agrochemicals
Precursor in the production of new drug candidates and pesticide formulations

Utility

Commonly employed in research and development for creating new molecules with potential applications in pharmaceutical and agricultural industries.

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 98-54-4 para-tert-butylphenol 

Relevant articles and documents

COMPOUNDS FOR THE TREATMENT OF ONCOVIRUS INDUCED CANCER AND METHODS OF USE THEREOF

The pesent invention relates to compounds of formula (I) pharmaceutically-acceptable salts, hydrates, solvates, or stereoisomers thereof and their use for the prevention and treatment of oncovirus induced cancer in a subject.

PROCESS FOR MAKING AMINO DIARYL ETHERS AND AMINO DIARYL ETHERS HYDROCHLORIDE SALTS

The present invention relates to a process for making a compound of formula (I) as described herein Formula (I) comprising reducing a compound of formula (II) as described herein with hydrogen in the presence of a palladium catalyst and a solvent wherein the solvent is a polar, aprotic solvent or a C3-C10 alcohol Formula (II). The present invention further relates to a hydrochloride salt and a monohydrochloride salt of the compound of formula (I) as described herein and to a process for making the same Formula (I)..

Inhibitors of notch signalling pathway and use thereof in treatment of cancers

The present invention relates to use of inhibitors of Notch signalling pathway selected from the group consisting of 6-(4-Tert-Butylphenoxy)Pyridin-3-Amine (I3), its derivatives, in treating and/or preventing cancers.

INHIBITORS OF NOTCH SIGNALLING PATHWAY AND USE THEREOF IN TREATMENT OF CANCERS

The present invention relates to use of inhibitors of Notch signalling pathway selected from the group consisting of 6-(4-Tert-Butylphenoxy)Pyridin-3-Amine (I3), its derivatives, in treating and/or preventing cancers.