- Catalytic enantioselective conjugate addition of carbamates
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Catalytic, asymmetric conjugate addition of carbamates to enoyl systems has been realized for the first time, providing a two-step access to virtually enantiopure N-protected β-amino acids. Copyright
- Palomo, Claudio,Oiarbide, Mikel,Halder, Rajkumar,Kelso, Michael,Gomez-Bengoa, Enrique,Garcia, Jesus M.
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p. 9188 - 9189
(2007/10/03)
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- α-Oxymethyl ketone enolates for the asymmetric Mannich reaction. From acetylene and N-alkoxycarbonylimines to β-amino acids
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The insufficient diastereoselectivity and generality, which are the main problems of the 'acetate' aza - aldol reaction, can now be addressed through the reaction of the lithium enolate of endo-O-trimethylsilyl acetyl isoborneol with various N[(p-tolylsul
- Palomo, Claudio,Oiarbide, Mikel,Gonzalez-Rego, M. Concepcion,Sharma, Arun K.,Garcia, Jesus M.,Gonzalez, Alberto,Landa, Cristina,Linden, Anthony
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p. 1063 - 1066
(2007/10/03)
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- (S)-β3-homolysine- and (S)-β3-homoserine-containing β-peptides: CD spectra in aqueous solution
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For further structural studies and for physiological investigations of β-peptides, it is necessary to have H2O-soluble derivatives. Thus, we have prepared β-hexa-, β-hepta-, and β-nonapeptides (1-6) with two, three, and seven side chains of lys
- Abele, Stefan,Guichard, Gilles,Seebach, Dieter
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p. 2141 - 2156
(2007/10/03)
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- A Concise Enantioselective Synthesis of Allylamines and N-Boc-β-Amino Acids
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A new and efficient enantioselective synthesis of allylamines and N-Boc-β-amino acids has been developed.Starting from enantiomerically enriched N-diphenylmethyl-3-amino-1,2-diols, allylamines are easily obtained by a Corey-Hopkins deoxygenative protocol.After a change in the nitrogen protecting group, the resulting N-Boc allylamines are converted into β-amino acids by hydroboration with 9-BBN followed by oxidation with PDC in DMF.
- Alcon, Montserrat,Canas, Marc,Poch, Marta,Moyano, Albert,Pericas, Miquel A.,Riera, Antoni
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p. 1589 - 1592
(2007/10/02)
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