21867-70-9 Usage
Uses
Used in Pharmaceutical Research:
1-(4-Ethoxybenzyl)piperazine is used as a building block for the synthesis of various bioactive molecules and pharmaceutical drugs due to its unique chemical structure and properties.
Used in Dopamine Receptor Research:
As a potential dopamine receptor ligand, 1-(4-Ethoxybenzyl)piperazine is used in the study and development of treatments for psychiatric disorders and neurological diseases, targeting the dopaminergic system.
Used in Medicinal Chemistry:
1-(4-Ethoxybenzyl)piperazine is employed in medicinal chemistry for its antiparasitic and antiviral activities, contributing to the development of new drugs to combat these health threats.
Used in Drug Development:
In the field of drug development, 1-(4-Ethoxybenzyl)piperazine serves as a valuable compound for creating novel therapeutic agents, particularly for psychiatric and neurological conditions, as well as for targeting parasitic and viral infections.
Check Digit Verification of cas no
The CAS Registry Mumber 21867-70-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,8,6 and 7 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 21867-70:
(7*2)+(6*1)+(5*8)+(4*6)+(3*7)+(2*7)+(1*0)=119
119 % 10 = 9
So 21867-70-9 is a valid CAS Registry Number.
InChI:InChI=1/C13H20N2O/c1-2-16-13-5-3-12(4-6-13)11-15-9-7-14-8-10-15/h3-6,14H,2,7-11H2,1H3
21867-70-9Relevant articles and documents
Design, synthesis and neuroprotective activities of novel cinnamide derivatives containing benzylpiperazine moiety
Zhong, Yan,Li, Xiaofeng,Zhang, Aixia,Xu, Yi,Li, Ping,Wu, Bin
, p. 1366 - 1373 (2018/02/28)
A new series of cinnamide derivatives 6a–l were synthesized by the reaction of acyl chlorides with various substituted benzylpiperazines. The structures were characterized by 1H NMR, 13C NMR, and HRMS. The potential neuroprotective activities of cinnamide analogs were evaluated in differentiated rat pheochromocytoma cells (PC12 cells) and in mice subjected to acute cerebral ischemia. Among the series, 6a, 6b, and 6c, featuring a 1,3-benzodioxole moiety, showed potent neuroprotection both in vivo and in vitro. The three compounds were selected and further studied to determine their mechanism of action. MTT assay, Hoechst 33342/PI double staining, and high content screening (HCS) revealed that pretreatment of the cells with 6a, 6b, and 6c has significantly decreased the extent of cell apoptosis in a dose-dependent manner. The results of western blot analysis demonstrated these compounds suppressed apoptosis of glutamate-induced PC12 cells via caspase-3 pathway. These compounds can be lead compounds for further discovery of neuroprotective agents for treating cerebral ischemic stroke.
