Environment-friendly non-toxic synthesis method of clenbuterol hydrochloride
The invention provides an environment-friendly non-toxic synthesis method of clenbuterol hydrochloride. The synthesis method comprises the following steps: 1) preparing an intermediate 1; 2) preparingan intermediate 2; 3) preparing clenbuterol; and 4) preparing the clenbuterol hydrochloride. The synthesis method comprises the following steps: synthesizing an intermediate 1 by adopting an oxidation method; and then forming a Schiff base intermediate 2 with tert-butylamine, and then preparing clenbuterol by reduction so that the condition that an alpha-bromo-structure intermediate with genotoxicity is prepared by using liquid bromine or other brominating agents in a traditional production process is avoided, the new synthesis method is environment-friendly and non-toxic, and the clinical use risk of clenbuterol hydrochloride is effectively reduced.
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Paragraph 0032; 0050; 0056-0059
(2020/07/21)
SUSTAINED RELEASING PATCH
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(2008/06/13)
Sustained release pharmaceutical plaster
A sustained release pharmaceutical plaster which is characterized in that it is a pharmaceutical preparation mainly composed of an adhesive compound layer and a supporter which supports the adhesive compound layer, inside of which there is an arrangement of hollow fibers, that have radially arranged open pores, with their tubular hollows filled with medicines.
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(2008/06/13)
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