- Novel angular benzophenazines: Dual topoisomerase I and topoisomerase II inhibitors as potential anticancer agents
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A series of substituted angular benzophenazines were prepared using a new synthetic route via a novel regiocontrolled condensation of 1,2-naphthoquinones and 2,3-diaminobenzoic acids. The synthesis and biological activity of this new series of substituted
- Vicker, Nigel,Burgess, Luke,Chuckowree, Irina S.,Dodd, Rory,Folkes, Adrian J.,Hardick, David J.,Hancox, Timothy C.,Miller, Warren,Milton, John,Sohal, Sukhjit,Wang, Shouming,Wren, Stephen P.,Charlton, Peter A.,Dangerfield, Wendy,Liddle, Chris,Mistry, Prakash,Stewart, Alistair J.,Denny, William A.
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p. 721 - 739
(2007/10/03)
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- Synthesis of (+/-)-Thienamycin based on a New Approach to β-Lactams via 4-Exo-trig Cyclisation of Carbamoylcobalt Salophens
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A series of N-propenyl substituted N-benzylcarbamoylcobalt(III) salophens, i.e., 11, 20 and 30, have been prepared, and have been shown to be useful precursors in a new approach to β-lactams (viz. 12 - 16, 21 and 31) via 4-exo-trig-modes of cyclisation of
- Pattenden, Gerald,Reynolds, Stephen J.
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p. 379 - 386
(2007/10/02)
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- A new synthetic route to (±)-thienamycin via 4-exo trigonal cyclisation of carbamoyl cobalt intermediates
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A new synthesis of (±)-thienamycin (1), based on elaboration of the key intermediate (12) in one step by heating a solution of the carbamoylcobalt salophen (11) in toluene, is described.
- Pattenden, Gerald,Reynolds, Stephen J.
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p. 259 - 262
(2007/10/02)
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