Diastereoselective Monofluorocyclopropanation Using Fluoromethylsulfonium Salts
Diarylfluoromethylsulfonium salts, alternatives to freons or advanced fluorinated building blocks, are bench stable and easy-to-use sources of direct fluoromethylene (:CHF) transfer to alkenes. These salts enabled development of a trans-selective monofluorinated Johnson-Corey-Chaykovsky reaction with vinyl sulfones or vinyl sulfonamides to access synthetically challenging monofluorocyclopropane scaffolds. The described method offers rapid access to monofluorinated cyclopropane building blocks with further functionalization opportunities to deliver more complex synthetic targets diastereoselectively.
Melngaile, Renate,Sperga, Arturs,Baldridge, Kim K.,Veliks, Janis
p. 7174 - 7178
(2019/09/12)
Fused benzo compounds containing a nitrogen heterocycle for the treatment of central nervous system disorders
Fused benzo compounds of formula I are provided, wherein A is a 2 to 6 membered hydrocarbon spacer group, B is a polar divalent group selected from a group (a); U is C, N or CH; X is a divalent 3-4 membered chain optionally comprising one or more heteroat
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(2008/06/13)
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