Studies in Acyl C-H activation via aryl and alkyl to acyl "through space" migration of palladium
Examples of the 1,4-migration of a palladium moiety in aryl- and alkylpalladium intermediates to the acyl position of an aldehyde or formamide have been observed. The resulting acylpalladium intermediate can undergo ester or carbamate formation by reaction with an alcohol; decarbonylation, followed by β hydride elimination to an alkene; reaction with an organomercurial to form an ester; or alkene insertion. Deuterium-labeling studies have been used to confirm the palladium migration mechanism.
Kesharwani, Tanay,Verma, Akhilesh K.,Emrich, Daniel,Ward, Jeffrey A.,Larock, Richard C.
Antimitotic agents interacting with tubulin: Synthesis and structure- activity relationships of novel ortho bridged biphenyis of the rhazinilam type
Several new ortho bridged biphenyls mimicking the structure of (-)- rhazinilam were synthesized and evaluated as cytotoxic compounds and as inhibitors of microtubules disassembly. These included azadibenzo[a,c]cyclononene derivatives having an ester, urea