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219736-10-4

(1-Cyclopropylpropyl)amine is an organic compound characterized by its cyclopropylpropyl amine structure. It is a versatile building block in the synthesis of various pharmaceutical compounds and has demonstrated potential in the development of novel therapeutic agents.

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  • 219736-10-4 Structure

  • Basic information

    1. Product Name: (1-Cyclopropylpropyl)amine
    2. Synonyms: (1-Cyclopropylpropyl)amine;1-cyclopropylpropan-1-amine
    3. CAS NO:219736-10-4
    4. Molecular Formula: C6H13N
    5. Molecular Weight: 99.17412
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 219736-10-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (1-Cyclopropylpropyl)amine(CAS DataBase Reference)
    10. NIST Chemistry Reference: (1-Cyclopropylpropyl)amine(219736-10-4)
    11. EPA Substance Registry System: (1-Cyclopropylpropyl)amine(219736-10-4)

  • Safety Data

    1. Hazard Codes: T
    2. Statements: 25-36
    3. Safety Statements: 26-45
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 219736-10-4(Hazardous Substances Data)

219736-10-4 Usage

Uses

Used in Pharmaceutical Industry:
(1-Cyclopropylpropyl)amine is used as a synthetic intermediate for the preparation of aryl(alkylamino)nitropyridines, pyridino, and pyrimidino pyrazinones. These compounds serve as corticotropin-releasing factor (CRF) receptor antagonists, which are being investigated for their potential in treating anxiety and depression. The amine's unique structure allows for the development of targeted therapies that can modulate the CRF system, offering a promising avenue for the treatment of these prevalent mental health conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 219736-10-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,9,7,3 and 6 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 219736-10:
(8*2)+(7*1)+(6*9)+(5*7)+(4*3)+(3*6)+(2*1)+(1*0)=144
144 % 10 = 4
So 219736-10-4 is a valid CAS Registry Number.

219736-10-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-cyclopropylpropan-1-amine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:219736-10-4 SDS

219736-10-4Upstream product

219736-10-4Relevant articles and documents

Synthetic method of cyclopropyl-containing chiral amine hydrochloride

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Paragraph 0031-0032; 0035, (2021/03/30)

The invention discloses a synthetic method of a medical intermediate cyclopropyl-containing chiral amine hydrochloride, and belongs to the field of synthesis and preparation of medical intermediates.According to the invention, a compound (I) cyclopropanecarboxaldehyde is used as an initial raw material, and a target product chiral amine hydrochloride is obtained through condensation, alkylation,debenzylation, chiral resolution and salification reactions. The synthetic method of the medicine intermediate cyclopropyl-containing chiral amine hydrochloride has the characteristics of low cost andsimple operation.

Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonists

Hartz, Richard A.,Ahuja, Vijay T.,Arvanitis, Argyrios G.,Rafalski, Maria,Yue, Eddy W.,Denhart, Derek J.,Schmitz, William D.,Ditta, Jonathan L.,Deskus, Jeffrey A.,Brenner, Allison B.,Hobbs, Frank W.,Payne, Joseph,Lelas, Snjezana,Li, Yu-Wen,Molski, Thaddeus F.,Mattson, Gail K.,Peng, Yong,Wong, Harvey,Grace, James E.,Lentz, Kimberley A.,Qian-Cutrone, Jingfang,Zhuo, Xiaoliang,Shu, Yue-Zhong,Lodge, Nicholas J.,Zaczek, Robert,Combs, Andrew P.,Olson, Richard E.,Bronson, Joanne J.,Mattson, Ronald J.,Macor, John E.

experimental part, p. 4173 - 4191 (2010/02/17)

Evidence suggests that corticotropin-releasing factor-1 (CRF1) receptor antagonistsmay offer therapeutic potential for the treatment of diseases associated with elevated levels of CRF such as anxiety and depression. A pyrazinone-based chemotype

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