219834-81-8

Basic information

• Product Name: 1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid,2,3-dihydro-1,1-diemthylethyl ester
• Synonyms: 1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid,2,3-dihydro-1,1-diemthylethyl ester;tert-butyl 2,3-dihydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate;1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid;1H-PYRROLO[3,2-C]PYRIDINE-1-CARBOXYLIC ACID, 2,3-DIHYDRO-, 1,1-DIMETHYLETHYL ESTER
• CAS NO: 219834-81-8
• Molecular Formula: C₁₂H₁₆N₂O₂
• Molecular Weight: 220.27
• Mol File: 219834-81-8.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid,2,3-dihydro-1,1-diemthylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid,2,3-dihydro-1,1-diemthylethyl ester(219834-81-8)
• EPA Substance Registry System: 1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid,2,3-dihydro-1,1-diemthylethyl ester(219834-81-8)

Safety Data

• Hazardous Substances Data: 219834-81-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid,2,3-dihydro-1,1-dimethylethyl ester is used as a reagent in pharmaceutical research and development for its ability to contribute to the synthesis of various drug compounds. Its unique structure allows it to be a key component in the creation of new pharmaceutical entities.
Used in Agrochemical Production:
In the agrochemical industry, 1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid,2,3-dihydro-1,1-dimethylethyl ester is used as a precursor in the synthesis of agrochemicals, playing a crucial role in the development of pesticides and other agricultural chemicals that protect crops and enhance yields.
Used in Organic Synthesis:
1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid,2,3-dihydro-1,1-dimethylethyl ester is utilized as an intermediate in organic synthesis, enabling the production of a wide range of organic compounds for various applications across different industries. Its versatility in chemical reactions makes it a valuable asset in the synthesis of complex organic molecules.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 148760-75-2 tert-butyl 1H-pyrrolo[3,2-c]pyridine-1-carboxylate 
• 271-29-4 6-azaindole 
• 504-24-5 4-aminopyridine 
• 219834-80-7 (tert-butoxy)-N-[3-(2-hydroxyethyl)(4-pyridyl)]carboxamide 
• 98400-69-2 N-(4-pyridyl) t-butyl carbamate 
• 23596-28-3 2,3-dihydro-1H-pyrrolo[3,2-c]pyridine 

Downstream Products

• 5912-19-6 2,3-dihydro-1H-pyrrolo[3,2-c]pyridine hydrochloride 
• 1147421-99-5 5-benzyl-octahydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester 
• 219834-92-1 1-(1-methyl(2-pyrrolino[2,3-d]pyridin-7-yl))-2-(phenylmethoxy)naphthalene 
• 23596-28-3 2,3-dihydro-1H-pyrrolo[3,2-c]pyridine 
• 219834-79-4 1-methyl-2,3-dihydro-1H-pyrrolo<3,2-c>pyridine 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES

Provided herein are Heterocyclic compounds of formula (I): and pharmaceutically acceptable salts, tautomers, isotopologues, or stereoisomers thereof, wherein W, X, Y, R1, R2, and RN are as defined herein, compositions comprising an effective amount of a Heterocyclic Compound, and methods for treating or preventing animal and human filarial worm infections and diseases.

Configurationally Stable Biaryl Analogues of 4-(Dimethylamino)pyridine: A Novel Class of Chiral Nucleophilic Catalysts

A short synthetic approach toward a novel class of chiral nucleophilic catalysts, the dissymmetry of which stems from restricted rotation about an Ar-Ar bond, has been developed. The key steps of the synthesis include preparation of a nucleophilic 1-methyl-2-pyrrolino[3,2-c]pyridine core 16 by ortho-lithiation and creation of the biaryl axes via Suzuki cross-coupling reactions. Comparative HPLC studies of racemization for configurationally labile biaryls 31, 38, and 43 containing 1-methyl-2-pyrrolino[3,2-c]pyridine, 4-(dimethylamino)pyridine, and 4-(1-pyrrolidino)pyridine cores, respectively, have demonstrated that a pyrrolidino substituent ortho to the biaryl axis is optimal for slowing Ar-Ar rotation. Biaryls containing all three cores have been shown to retain DMAP-like catalytic activity in the acylation of a hindered alcohol. Biaryls 55 and 56, which are configurationally stable at ambient temperature, have also been prepared via modification of configurationally labile derivatives. Compounds 55 and 56 in optically pure form should provide a useful starting point for studies on catalytic asymmetric acyl transfer using atropisomeric analogues of DMAP.

Synthesis of atropisomeric analogues of DMAP

A method for the preparation of 7-aryl derivatives of N-methyl-5- azaindolinee involving Suzuki cross-coupling is described. Certain biaryls prepared in this manner exhibit atropisomerism. In particular, azaindoline 11 is shown to be configurationally sta