Aryl- and arylamino- substituted heterocycles as corticotropin releasing hormone antagonists
Corticotropin releasing factor (CRF) antagonists of formula I: and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress in mammals.
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(2008/06/13)
4-Aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists
A series of 4-aryl-2-(N-ethylanilino)pyrimidines has been synthesized as corticotropin-releasing hormone (CH) inhibitors. The effect of substitution on each aromatic ring on receptor binding was investigated.
Cocuzza, Anthony J.,Hobbs, Frank W.,Arnold, Charles R.,Chidester, Dennis R.,Yarem, Jerry A.,Culp, Steven,Fitzgerald, Lawrence,Gilligan, Paul J.
p. 1057 - 1062
(2007/10/03)
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