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220150-71-0

2-Methylpropionic acid 2-(2-amino-6-fluoro-9H-purin-9-ylmethoxy)ethyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 220150-71-0 Structure

  • Basic information

    1. Product Name: 2-Methylpropionic acid 2-(2-amino-6-fluoro-9H-purin-9-ylmethoxy)ethyl ester
    2. Synonyms:
    3. CAS NO:220150-71-0
    4. Molecular Formula: C12H16FN5O3
    5. Molecular Weight: 297.29142
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 220150-71-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-Methylpropionic acid 2-(2-amino-6-fluoro-9H-purin-9-ylmethoxy)ethyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-Methylpropionic acid 2-(2-amino-6-fluoro-9H-purin-9-ylmethoxy)ethyl ester(220150-71-0)
    11. EPA Substance Registry System: 2-Methylpropionic acid 2-(2-amino-6-fluoro-9H-purin-9-ylmethoxy)ethyl ester(220150-71-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 220150-71-0(Hazardous Substances Data)

220150-71-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 220150-71-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,1,5 and 0 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 220150-71:
(8*2)+(7*2)+(6*0)+(5*1)+(4*5)+(3*0)+(2*7)+(1*1)=70
70 % 10 = 0
So 220150-71-0 is a valid CAS Registry Number.

220150-71-0Downstream Products

220150-71-0Relevant articles and documents

Synthesis and evaluation of 2-amino-6-fluoro-9-(2-hydroxyethoxymethyl)purine esters as potential prodrugs of acyclovir

Kim, Dae-Kee,Lee, Namkyu,Im, Guang-Jin,Kim, Hun-Taek,Kim, Key H.

, p. 2525 - 2530 (2007/10/03)

2-Amino-6-fluoro-9-(2-hydroxyethoxymethyl)purine (2) and its ester derivatives 4a-d were synthesized as potential prodrugs of acyclovir, and were evaluated for their oral acyclovir bioavailability in rats and in vivo antiviral efficacy in HSV-1-infected mice. Treatment of 2-amino-6-chloro-9-(2-hydroxyethoxymethyl)purine (3) with trimethylamine in THF/DMF (4:1) followed by a reaction of the resulting trimethylammonium chloride salt 5 with KF in DMF gave 2 in 78% yield. Esterification of 2 with an appropriate acid anhydride (Ac2O, (EtCO)2O, (n-PrCO)2O, or (i-PrCO)2O) in DMF in the presence of a catalytic amount of DMAP at room temperature produced the esters 4a-d in 90-98% yields. Of the prodrugs tested in rats, the isobutyrate 4d achieved the highest mean urinary recovery of acyclovir (51%) that is 5.7-fold higher than that of acyclovir (9%) and comparable to that of valacyclovir (50%). The prodrug 4d protected dose-dependently the mortality of HSV-1-infected mice, and the group treated with 4d at a dose of 400mg/kg showed the longest mean survival day (14.6±3.1 days) (mean±S.D.). Copyright (C) 1998 Elsevier Science Ltd.

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