This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein R2 is a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).
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Page/Page column 195-196
(2009/07/17)
Benzotriazine inhibitors of kinases
The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
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Page/Page column 74
(2008/06/13)
A New Synthesis of Lysergic Acid
(Equation presented) (±)-Lysergic acid (1) has been synthesized via an economical 8-step route from 4-bromoindole and isocinchomeronic acid without the need to protect the indole during the synthesis. Initial efforts to form the simpler 3-acylindole derivatives first and then cyclize these were unsuccessful in the cyclization step.
Hendrickson, James B.,Wang, Jian
p. 3 - 5
(2007/10/03)
4-ARYLOXINDOLES
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(2008/06/13)
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