220641-87-2

Basic information

• Product Name: METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL
• Synonyms: METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE;METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL;METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HYDROCHLORIDE;CHEMBRDG-BB 4003545;N-METHYL-N-TETRAHYDRO-2H-PYRAN-4-YLAMINE;N-METHYL-TETRAHYDRO-2H-PYRAN-4-AMINE;N-METHYL-TETRAHYDRO-2H-PYRAN-4-AMINE HYDROCHLORIDE;4-(Methylamino)tetrahydro-2H-pyran
• CAS NO: 220641-87-2
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.17352
• Mol File: 220641-87-2.mol

Chemical Properties

• Boiling Point: 165 °C at 760 mmHg
• Flash Point: 56.1 °C
• Appearance: /
• Density: 0.93 g/cm³
• Vapor Pressure: 1.91mmHg at 25°C
• Refractive Index: 1.448
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.01±0.20(Predicted)
• CAS DataBase Reference: METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL(220641-87-2)
• EPA Substance Registry System: METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL(220641-87-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 220641-87-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure allows for the creation of diverse chemical entities with potential medicinal properties.
Used in Agrochemical Industry:
In the agrochemical sector, METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL is utilized as a component in the synthesis of agrochemicals, such as pesticides and herbicides, to enhance crop protection and yield.
Used in Organic Synthesis:
METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL is used as a reagent in organic synthesis processes, facilitating the production of fine chemicals and pharmaceutical intermediates. Its presence in these reactions can lead to the formation of complex molecules with specific applications in various industries.
Used in Research and Development:
METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL is also employed in research and development settings, where it can be used to explore new chemical reactions, investigate its properties, and discover novel applications in different fields, including material science and chemical engineering.

InChI:InChI=1/C6H13NO/c1-7-6-2-4-8-5-3-6/h6-7H,2-5H2,1H3

Upstream product

• 229007-08-3 N-[(4-nitrophenyl)methyl]tetrahydro-N-methyl-2H-pyran-4-amine 
• 874888-66-1 4-[N-(tetrahydropyran-4-yl)aminomethyl]-nitrobenzene 

Downstream Products

• 220641-84-9 N-methyl-N-(tetrahydropyran-4-yl)carbamoyl chloride 

Relevant articles and documents

Hydrogenation of (N,N-disubstituted aminomethyl)nitrobenzenes to (N,N-disubstituted aminomethyl)anilines catalyzed by palladium-nickel bimetallic nanoparticles

Since palladium-catalysts have strong abilities for both hydrogenation of nitro-group and hydrogenolysis of benzylamine, they have a much lower chemoselectivity for the hydrogenation of (N,N-disubstituted aminomethyl)nitrobenzenes. In this article, component stable Pd-Ni bimetallic nanoparticles were prepared by simply heating RANEY-Ni and Na2PdCl4 together in water. They demonstrated novel synergistic effects when they were used as a bimetallic catalyst, by which a highly efficient and chemoselective hydrogenation of (N,N-disubstituted aminomethyl)nitrobenzenes to (N,N-disubstituted aminomethyl)anilines was achieved.

Process development of 4-[N-methyl-N-(tetrahydropyran-4-yl)aminomethyl]aniline dihydrochloride: A key intermediate for TAK-779, a small-molecule nonpeptide CCR5 antagonist

A new and efficient synthesis of 4-[N-methyl-N-(tetrahydropyran-4-yl)aminomethyl]aniline dihydrochloride, a key intermediate for the CCR5 antagonist TAK-779, is described. Reductive alkylation of methylamine with tetrahydro-4H-pyran-4-one followed by alkylation of N-methyl-N-(tetrahydropyran-4-yl)amine with 4-nitrobenzylbromide and reduction of N-(4-nitrobenzyl)-N-(tetrahydropyran-4-yl)amine results in a 78% isolated yield from the starting materials by a scalable method, using only commercially available reagents.