220664-32-4

Basic information

• Product Name: 3-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER
• Synonyms: METHYL 3-CHLORO-1H-INDOLE-2-CARBOXYLATE;3-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER;3-Chloro-2-(methoxycarbonyl)-1H-indole
• CAS NO: 220664-32-4
• Molecular Formula: C10H8ClNO2
• Molecular Weight: 209.63
• Product Categories: pharmacetical
• Mol File: 220664-32-4.mol

Chemical Properties

• Melting Point: 168-170°C
• Appearance: /
• CAS DataBase Reference: 3-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER(220664-32-4)
• EPA Substance Registry System: 3-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER(220664-32-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 220664-32-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER is used as a chemical intermediate for the synthesis of arylamide derivatives. These derivatives have potential applications as EP4 receptor antagonists, which are important in the development of drugs targeting various inflammatory and pain-related conditions.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID METHYL ESTER serves as a key building block for the creation of more complex molecules with diverse applications. Its unique structural features make it a valuable component in the design and synthesis of novel compounds with potential uses in various industries, including pharmaceuticals, materials science, and agrochemicals.

Upstream product

• 1202-04-6 indole-2-carboxylic acid methyl ester 

Relevant articles and documents

Amide derivative and application thereof in preparation of EP4 receptor antagonist

The invention discloses a compound shown as a formula I. The compound can be used as an EP4 receptor antagonist of PGE2, inhibits enzyme and cell proliferation, and is used for treating diseases related to an EP4 receptor, including cancers, inflammatory diseases, pains and other indications.

N-Chloro-N-methoxybenzenesulfonamide: A Chlorinating Reagent

A structurally simple and reactive chlorinating reagent, N-chloro-N-methoxybenzenesulfonamide, was conveniently and economically prepared in high yield. 1,3-Diketones, β-keto esters, benzoyl trifluoroacetones, phenols, anisoles, heteroarenes, and aromatic amines were successfully chlorinated, and the products were obtained in good to high yields.

Indole derivatives as MCP-1 receptor antagonists

The invention concerns pharmaceutically useful indoles of formula (I), in which Z, X, T, A, R1, R2, p and q have any of the meanings defined herein, and their pharmaceutically acceptable salts or in vivo hydrolysable esters, as well