Preventive and/or Therapeutic Agent for Diabetic Vascular Disorder and Respiratory Disorder
The present invention provides preventive and/or therapeutic agents for either one, or both, of a diabetic vascular disorder and a diabetic respiratory disorder comprising, as an active ingredient, a cyclohexenone long chain alcohol compound represented b
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(2009/01/24)
THERAPEUTIC AGENT FOR SENSORY ABNORMALITY
The present invention provides therapeutic agents for sensory disorders represented by the following formula (1): [wherein R1, R2, and R3 each represent a hydrogen atom or a methyl group, and X represents a linear or branc
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Page/Page column 15
(2008/06/13)
CYCLOHEXENONE LONG-CHAIN ALCOHOL FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS
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(2008/06/13)
Cyclohexenone long-chain alcohol and medicament containing same
Described is a cyclohexenone long-chain alcohol represented by the formula (1): wherein R1, R2 and R3 each independently represents a hydrogen atom or a methyl group and X represents a C10-18 alkylene or alkenylene group. The cyclohexanone long-chain alco
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(2008/06/13)
Cyclohexenonic long-chain fatty alcohols as neuronal growth stimulators
Neurotrophic factors play an important role in the development and maintenance of neurons, thus providing a suitable therapeutic approach for the treatment of neurodegenerative diseases. However, their clinical use has revealed problematic because of a number of technical and biological disadvantages. Among the different strategies proposed to overcome such difficulties, the search for non-peptide substances with neurotrophic potential is giving promising results. Here we will expose major findings in this field, drawing special attention to cyclohexenonic long-chain fatty alcohols, a novel family of compounds that promote neuronal survival and neurite outgrowth.
Luu, Bang,Gonzalez De Aguilar, Jose-Luis,Girlanda-Junges, Celine
p. 1439 - 1460
(2007/10/03)
Effect of cyclohexenonic long chain fatty alcohols on neurite outgrowth. Study on structure-activity relationship
Four series of long chain fatty alcohols bearing a cyclohexenone moiety in addition to a ω-alkanol side chain were synthesized using 'Umpolung' reactivity strategy. Their effect on neurite outgrowth was evaluated by means of fetal rat neurons in culture. The length of the ω-hydroxy side chain is a crucial factor for biological activity.
Girlanda-Junges, Celine,Keyling-Bilger, Florence,Schmitt, Gaby,Luu, Bang
p. 7735 - 7748
(2007/10/03)
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