220835-17-6

Basic information

• Product Name: 7-(4-METHOXYPHENYL)-5-PHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-OL
• Synonyms: IFLAB-BB F1386-0307;7-(4-METHOXYPHENYL)-5-PHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-OL;AKOS BBS-00002078
• CAS NO: 220835-17-6
• Molecular Formula: C₁₉H₁₅N₃O₂
• Molecular Weight: 317.34
• Mol File: 220835-17-6.mol

Chemical Properties

• Boiling Point: 599.3±50.0 °C(Predicted)
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• PKA: 9.27±0.20(Predicted)
• CAS DataBase Reference: 7-(4-METHOXYPHENYL)-5-PHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(4-METHOXYPHENYL)-5-PHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-OL(220835-17-6)
• EPA Substance Registry System: 7-(4-METHOXYPHENYL)-5-PHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-OL(220835-17-6)

Safety Data

• Hazardous Substances Data: 220835-17-6(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 61404-71-5 2-amino-1-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-3-carbonitrile 
• 5883-82-9 2-((4-methoxyphenyl)amino)-1-phenylethanone 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 220835-25-6 4-chloro-7-(4-methoxyphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine 
• 121405-26-3 7-(4-Methoxy-phenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine 
• 220835-48-3 7-(4-methoxy-phenyl)-9-phenyl-7H-pyrrolo[3,2-e]tetrazolo[1,5-c]pyrimidine 
• 890091-07-3 7-(4-methoxyphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-thione 
• 1649461-03-9 C₂₁H₁₉N₃O₂ 
• 1649461-04-0 C₂₂H₂₀ClN₃O₂ 
• 1649461-05-1 C₂₆H₂₁N₃O₂ 

Relevant articles and documents

Synthesis of 5,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidin-4(3H)-ones and their N-alkylation's under phase transfer conditions

5,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidin-4(3H)-ones 2 were synthesized by the cyclocondensation of 1,4-disubstituted 2-amino-3-cyanopyrrole 1 with formic acid. When comparative study of N versus O alkylation of ambident 5,7-disubstituted 7H-pyrrolo[2,3-d]pyrimidin-4(3H)-ones 2 was carried out under liquid-liquid PTC, solid-liquid PTC, and solid-liquid solvent free conditions using various alkylating agents 3, the N-alkylated product 4 were obtained selectively and exclusively.

Synthesis and kinetic testing of new inhibitors for a metallo-β- lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa

There are currently no clinically useful inhibitors against metallo-β-lactamases (MBLs), enzymes that confer resistance against a broad spectrum of commonly used antibiotics and that are produced by an increasing number of bacterial pathogens. New pyrrole

Synthesis of 7H-tetrazolo[1,5-c]pyrrolo[3,2-e]pyrimidines and their reductive ring cleavage to 4-aminopyrrolo[2,3-d]pyrimidines

Some new 7,9-disubstituted 7H-1,2,3,4-tetrazolo[1,5-c]pyrrolo[3,2- e]pyrimidines 5 have been synthesized either by diazotization of 4-hydrazino- 5,7-disubstituted-7H-pyrrolo[2,3-d]pyrimidines 4 obtained by hydrazinolysis of 4-chloro-5,7-disubstituted-7H-pyrrolo[2,3-d]pyrimidines 3 or via a substitution reaction between 3 and sodium azide. 5,7-Disubstituted-7H- pyrrolo[2,3-d]pyrimidin-4(3H)-ones 2 were obtained by cyclocondensation of 2- amino-3-cyano-1,4-disubstituted pyrroles 1 with formic acid which on chlorination using phosphorus oxychloride afforded 3. A novel route for the synthesis of 4-amino-5,7-disubstituted-7H-pyrrolo[2,3-d]pyrimidines 6 by the reductive ring cleavage of 5 has been reported.