220998-36-7

Basic information

• Product Name: (3-BroMo-2,6-diMethoxy-4-pyridyl)diphenylphosphine oxide
• Synonyms: (3-BroMo-2,6-diMethoxy-4-pyridyl)diphenylphosphine oxide
• CAS NO: 220998-36-7
• Molecular Formula: C₁₉H₁₇BrNO₃P
• Molecular Weight: 418.220941
• Mol File: 220998-36-7.mol

Chemical Properties

• Melting Point: 166-169℃
• Appearance: /
• CAS DataBase Reference: (3-BroMo-2,6-diMethoxy-4-pyridyl)diphenylphosphine oxide(CAS DataBase Reference)
• NIST Chemistry Reference: (3-BroMo-2,6-diMethoxy-4-pyridyl)diphenylphosphine oxide(220998-36-7)
• EPA Substance Registry System: (3-BroMo-2,6-diMethoxy-4-pyridyl)diphenylphosphine oxide(220998-36-7)

Safety Data

• Hazardous Substances Data: 220998-36-7(Hazardous Substances Data)

Usage

Uses

Used in Coordination Chemistry:
(3-Bromo-2,6-dimethoxy-4-pyridyl)diphenylphosphine oxide is used as a ligand for forming stable complexes with transition metal ions. Its complexation properties are beneficial in coordination chemistry, where it can enhance the stability and reactivity of metal complexes.
Used in Organic Synthesis:
In the field of organic synthesis, (3-Bromo-2,6-dimethoxy-4-pyridyl)diphenylphosphine oxide serves as a reagent, contributing to the formation of various organic compounds. Its unique structure allows it to participate in a range of reactions, making it a valuable tool for synthetic chemists.
Used in Catalysis:
Due to its ability to form stable complexes with transition metal ions, (3-Bromo-2,6-dimethoxy-4-pyridyl)diphenylphosphine oxide is also used in catalytic applications. It can improve the efficiency of catalytic processes by stabilizing the catalyst and facilitating the reaction.
Used in Medicinal Chemistry:
(3-Bromo-2,6-dimethoxy-4-pyridyl)diphenylphosphine oxide has been studied for its potential use in medicinal chemistry, primarily due to its biological activity. Its unique structure and properties make it a promising candidate for the development of new pharmaceuticals and therapeutic agents.

Upstream product

• 6231-18-1 2,6-dimethoxypyridine 
• 13445-16-4 3-bromo-2,6-dimethoxypyridine 
• 220998-35-6 3-bromo-2,6-dimethoxy-4-diphenylphosphino-pyridine 

Downstream Products

• 677354-34-6 2,6-dimethoxy-4-diphenylphosphinoylpyridine 
• 1160169-94-7 2,6-dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 
• 220998-37-8 (+/-)-2,2',6,6'-tetramethoxy-bis(diphenylphosphinoyl)-3,3'-bipyridine 

Relevant articles and documents

The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents

A series of 2,6-dimethoxylpyridinyl phosphine oxides have been synthesized and examined for their antitumor activity. 2,6-Dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 2 has been employed as the lead compound for this study. We found out that the prese

A convenient synthesis of 2,2′,6,6′-tetramethoxy-4,4′- bis(dicyclohexylphosphino)-3,3′-bipyridine (Cy-P-Phos): Application in Rh-catalyzed asymmetric hydrogenation of α-(acylamino)acrylates

The first example of the synthesis of an axially chiral bis(aryldicyclohexylphosphine) dioxide via catalytic hydrogenation of the optically resolved parent bis(aryldipnenylphosphine) dioxide was reported. The procedure for the synthesis of Cy-P-Phos (4d)

Chiral pyridylphosphines and their application in asymmetric catalytic hydrogenation of 2-arylpropenoic acids

Novel, optically active phosphorous compounds of the formula, STR1 wherein R1 represents hydrogen atoms, straight or branched-chain alkyl groups having from 1 to 6 carbon atoms, R2 represents hydrogen atoms, halogen atoms, lower alkyl groups (1 to 6 carbon atoms), lower alkoxy groups (1 to 6 carbon atoms), hydroxy group, chiral hydroxyalkyl groups, and amino groups (1°, 2°, 3°) vinyl groups or allyl groups and R3 represents phenyl groups, aryl groups, cyclohexyl groups, substituted and unsubstituted cycloalkyl groups, heteroaromatic rings, are described. The compounds of the formula serve as highly useful ligands in the preparation of ruthenium complexes which are effective catalysts for the asymmetric hydrogenation of 2-arylpropenoic acids leading to high valued 2-arylpropionic acids.