- The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents
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A series of 2,6-dimethoxylpyridinyl phosphine oxides have been synthesized and examined for their antitumor activity. 2,6-Dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 2 has been employed as the lead compound for this study. We found out that the prese
- Lam, Kim Hung,Gambari, Roberto,Yuen, Marcus Chun Wah,Kan, Chi Wai,Chan, Penni,Xu, Lijin,Tang, Weijun,Chui, Chung Hin,Cheng, Gregory Yin Ming,Wong, Raymond Siu Ming,Lau, Fung Yi,Tong, Cindy Sze Wai,Chan, Andrew Kit Wah,Lai, Paul Bo San,Kok, Stanton Hon Lung,Cheng, Chor Hing,Chan, Albert Sun Chi,Tang, Johnny Cheuk On
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scheme or table
p. 2266 - 2269
(2009/12/25)
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- A convenient synthesis of 2,2′,6,6′-tetramethoxy-4,4′- bis(dicyclohexylphosphino)-3,3′-bipyridine (Cy-P-Phos): Application in Rh-catalyzed asymmetric hydrogenation of α-(acylamino)acrylates
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The first example of the synthesis of an axially chiral bis(aryldicyclohexylphosphine) dioxide via catalytic hydrogenation of the optically resolved parent bis(aryldipnenylphosphine) dioxide was reported. The procedure for the synthesis of Cy-P-Phos (4d)
- Wu, Jing,Au-Yeung, Terry T.-L.,Kwok, Wai-Him,Ji, Jian-Xin,Zhou, Zhongyuan,Yeung, Chi-Hung,Chan, Albert S. C.
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p. 507 - 511
(2007/10/03)
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- Chiral pyridylphosphines and their application in asymmetric catalytic hydrogenation of 2-arylpropenoic acids
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Novel, optically active phosphorous compounds of the formula, STR1 wherein R1 represents hydrogen atoms, straight or branched-chain alkyl groups having from 1 to 6 carbon atoms, R2 represents hydrogen atoms, halogen atoms, lower alkyl groups (1 to 6 carbon atoms), lower alkoxy groups (1 to 6 carbon atoms), hydroxy group, chiral hydroxyalkyl groups, and amino groups (1°, 2°, 3°) vinyl groups or allyl groups and R3 represents phenyl groups, aryl groups, cyclohexyl groups, substituted and unsubstituted cycloalkyl groups, heteroaromatic rings, are described. The compounds of the formula serve as highly useful ligands in the preparation of ruthenium complexes which are effective catalysts for the asymmetric hydrogenation of 2-arylpropenoic acids leading to high valued 2-arylpropionic acids.
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