Metalation of 3-trimethylsilyl propargyl chloride: A stereoselective access to trans-propargylic oxiranes
The metalation of 3-trimethylsilyl-1-chloroprop-2-yne and the subsequent reaction with aldehydes affords stereospecifically anti-chlorohydrins which give after treatment with potassium fluoride and NaOH propargylic epoxides with good to excellent yields.
Chemla, Fabrice,Bernard, Nicolas,Normant, Jean F.
p. 75 - 78
(2007/10/03)
Use of α-chlorosulfides in indium promoted C-C couplings: Easy entry into the stereoselective formation of epoxy alkynes
The use of α-chlorosulfide compounds to control stereoselectivity in indium promoted C-C couplings occurs smoothly at room temperature under aqueous and mixed aqueous/organic conditions. Use of the halide to control synlanti ratios simplifies the indium p
Engstrom, Gregory,Morelli, Meisha,Palomo, Carolyn,Mitzel, Thomas
p. 5967 - 5970
(2007/10/03)
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