- Preparation method of N, N, N'-trimethyl-N'-ethoxyl-ethanediamine
-
The invention discloses a preparation method of N, N, N'-trimethyl-N'-ethoxyl-ethanediamine. The preparation method comprises the following steps: adding hydroxyethyl ethylenediamine and paraformaldehyde to a vessel, and dropwise adding formic acid in stirring, wherein the molar ratio of hydroxyethyl ethylenediamine to paraformaldehyde to formic acid is 1: (3-3.3): (3-3.3), and the reaction is carried out for 1 to 2 hours at the temperature of 50 to 110 DEG C; performing pressure-reduction steaming to obtain water generated in the reaction after the reaction is finished, so as to obtain reacting liquid; adding alcohols substances to the obtained reacting liquid to perform an ester exchange reaction so as to obtain purified reacting liquid; and performing pressure-reduction distilling on the obtained reacting liquid so as to separate out the alcohols substance and N, N, N'-trimethyl-N'-ethoxyl-ethanediamine, wherein the alcohols substances are recycled.
- -
-
Paragraph 0040-0064
(2017/07/19)
-
- Synthesizing method for N,N,N'-trimethyl-N'-ethoxyl-ethidene diamine
-
The invention discloses a synthesizing method for N,N,N'-trimethyl-N'-ethoxyl-ethidene diamin.The synthesizing method comprises the following steps that firstly, synthesizing is carried out, wherein ethoxyl ethylenediamine, methanal substances, a catalyst and hydrogen are added into an autoclave to carry out a reaction in a sealed state with the reaction temperature ranging from 80 DEG C to 120 DEG C, the reaction pressure regulated with hydrogen to be 0-3 MPa and the reaction time ranging from 3 h to 7 h, the autoclave is opened after the reaction is finished, reaction liquor is filtered, and filter liquor is collected; secondly, separating is carried out, wherein the filter liquor obtained in the first step is subjected to atmospheric distillation to remove water, vacuum distillation is carried out, and N,N,N'-trimethyl-N'-ethoxyl-ethidene diamin is obtained.
- -
-
Paragraph 0026; 0032-0038
(2017/04/03)
-
- 2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION
-
The present invention has its object to provide a 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented with the Formula (1) , or the pharmaceutically acceptable salt, which is effective as a therapeutic and prophylactic agent for diabetes, diabetic nephropathy, or glomerulosclerosis.
- -
-
-
- A simple HPLC-UV method for the determination of dimenhydrinate and related substances - Identification of an unknown impurity
-
During the revision of the dimenhydrinate monograph of the European Pharmacopoeia a HPLC-UV method was developed. The procedure described allows a qualitative and quantitative determination of both dimenhydrinate compounds and of thirteen related substances. Furthermore a hitherto unknown impurity was identified and integrated into the purity check. Also 18 samples of dimenhydrinate have been tested. Thereby the relevant impurities of dimenhydrinate could be nominated and quantified.
- Doege, Ulrica,Eger
-
p. 174 - 178
(2008/02/01)
-
- Process for converting heat stable amine salts to heat regenerable amine salts
-
Processes are disclosed for converting heat stable amine salts to heat regenerable amine salts using a modified electrodialysis zone (140). The processes of the present invention can be used to reduce the level of heat stable salts in a lean solvent stream in an acid gas removal process and can be integrated with the acid gas removal process to utilize process streams as a source of ions.
- -
-
-
