221615-73-2

Basic information

• Product Name: 3 aMino-2-chloroacrolein
• Synonyms: 3 aMino-2-chloroacrolein;3-amino-2-chloro-2-Propenal;3-Amino-2-chloro-propenal
• CAS NO: 221615-73-2
• Molecular Formula: C₃H₄ClNO
• Molecular Weight: 105.52296
• Mol File: 221615-73-2.mol

Chemical Properties

• Boiling Point: 316.3±27.0 °C(Predicted)
• Appearance: /
• Density: 1.258±0.06 g/cm3 (20 oC 760 Torr), Calc.*
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 2.01±0.70(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: 3 aMino-2-chloroacrolein(CAS DataBase Reference)
• NIST Chemistry Reference: 3 aMino-2-chloroacrolein(221615-73-2)
• EPA Substance Registry System: 3 aMino-2-chloroacrolein(221615-73-2)

Safety Data

• Hazardous Substances Data: 221615-73-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3 aMino-2-chloroacrolein is used as a chemical reagent for the synthesis of a COX-2 specific inhibitor. COX-2 inhibitors are nonsteroidal anti-inflammatory drugs (NSAIDs) that selectively target the cyclooxygenase-2 enzyme, which is involved in inflammation and pain. By inhibiting COX-2, these drugs can provide effective pain relief and reduce inflammation with fewer side effects compared to traditional NSAIDs that inhibit both COX-1 and COX-2 enzymes.

Upstream product

• 58668-69-2 2-Chlor-3-p-toluidinopropenal 

Downstream Products

• 202409-33-4 etoricoxib 

Relevant articles and documents

A backing tests the past intermediate 3-amino-2-chloro acrolein preparation method (by machine translation)

The invention discloses a backing tests the past intermediate 3-amino-2-chloro acrolein preparation method. The method is to rice polishings chloric acid as the starting material, the methyl aniline with rice polishings chloric acid reaction, got the midbody 7 ; intermediate 7 intermediate hydrolysis of the organic acid in 8, intermediate 8 in ammonia water reaction to obtain the 3-amino-2-chloro acrolein. The invention adopts the methyl aniline as solid, low toxicity, nucleophilicity than aniline is strong, has high yield; the invention greatly simplifies the operating steps, the production cost is reduced, more favorable to commercial reaction; post-treating process of the present invention is more simple, the on the basis of the impurity removal efficiency is improved, further reducing the complexity of the operation of the process. (by machine translation)