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CAS

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221635-42-3

2,5-Di(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 2,5-Cyclohexadiene-1,4-dione,2,5-bis(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-

    Cas No: 221635-42-3

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  • 221635-42-3 Structure

  • Basic information

    1. Product Name: 2,5-Di(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone
    2. Synonyms: NSC-697726; RH1; 2,5-bis(aziridin-1-yl)-3-(hydroxymethyl)-6-methylcyclohexa-2,5-diene-1,4-dione
    3. CAS NO:221635-42-3
    4. Molecular Formula: C12H14N2O3
    5. Molecular Weight: 234.2512
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 221635-42-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 424.8°C at 760 mmHg
    3. Flash Point: 210.7°C
    4. Appearance: N/A
    5. Density: 1.536g/cm3
    6. Vapor Pressure: 5.38E-09mmHg at 25°C
    7. Refractive Index: 1.712
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2,5-Di(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2,5-Di(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone(221635-42-3)
    12. EPA Substance Registry System: 2,5-Di(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone(221635-42-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 221635-42-3(Hazardous Substances Data)

221635-42-3 Usage

Origin

Derived from the bacterium Streptomyces caespitosus

Classification

Powerful antibiotic and antitumor agent

Mechanism of action

Causes DNA and RNA cross-linking, leading to cell death
Stomach cancer
Pancreas cancer
Bladder cancer
Lung cancer
Glaucoma
Rheumatoid arthritis

Side effects

Can cause bone marrow depression and suppress the immune system

Medical considerations

Requires careful monitoring and dosing adjustments during treatment

Check Digit Verification of cas no

The CAS Registry Mumber 221635-42-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,1,6,3 and 5 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 221635-42:
(8*2)+(7*2)+(6*1)+(5*6)+(4*3)+(3*5)+(2*4)+(1*2)=103
103 % 10 = 3
So 221635-42-3 is a valid CAS Registry Number.

221635-42-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,5-di(aziridin-1-yl)-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone

1.2 Other means of identification

Product number -
Other names RH1

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:221635-42-3 SDS

221635-42-3Relevant articles and documents

DT-DIAPHORASE-ACTIVE AGENTS FOR TREATMENT OF PEDIATRIC TUMORS

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Page/Page column 12, (2009/05/29)

The present invention is directed to methods for treating patients having a pediatric cancer, comprising administering to a patient an effective amount of the compound 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1). The cancer can incl

COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF CANCER

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Page/Page column 28, (2008/06/13)

The present invention relates to the use of a therapeutically effective amount of 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1), in the manufacture of a medicament for the treatment of a cancerous condition.

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