Palladium-Catalyzed Decarbonylative Difluoromethylation of Acid Chlorides at Room Temperature
Methods for the direct synthesis of difluoromethylated arenes are sparse, despite the importance of the difluoromethyl group in medical, agro-, and materials chemistry. A palladium-catalyzed decarbonylative cross-coupling reaction of acid chlorides with a difluoromethyl zinc reagent is achieved to access difluoromethylated compounds. The transformation proceeds at room temperature and shows broad functional group tolerance, thus providing a general and efficient method for decarbonylative difluoromethylation of a wide range of aromatic carboxylic acids.
Pan, Fei,Boursalian, Gregory B.,Ritter, Tobias
supporting information
p. 16871 - 16876
(2018/11/23)
Benzamidine derivatives as factor XA inhibitors
Novel compounds of the formula I in which X, Y, R1, R2and R3are as defined in Patent Claim 1 are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders.
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(2008/06/13)
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