222551-24-8

Basic information

• Product Name: 2-(4-FLUORO-PHENYL)-4-METHYL-PYRIDINE
• Synonyms: 2-(4-FLUORO-PHENYL)-4-METHYL-PYRIDINE
• CAS NO: 222551-24-8
• Molecular Formula: C₁₂H₁₀FN
• Molecular Weight: 187.2129032
• Mol File: 222551-24-8.mol

Chemical Properties

• Boiling Point: 282.436 °C at 760 mmHg
• Flash Point: 124.613 °C
• Appearance: /
• Density: 1.112 g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-FLUORO-PHENYL)-4-METHYL-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUORO-PHENYL)-4-METHYL-PYRIDINE(222551-24-8)
• EPA Substance Registry System: 2-(4-FLUORO-PHENYL)-4-METHYL-PYRIDINE(222551-24-8)

Safety Data

• Hazardous Substances Data: 222551-24-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Fluoro-phenyl)-4-methyl-pyridine is used as a building block for the synthesis of various biologically active compounds. Its unique structure and reactivity make it a valuable component in the development of new drugs, contributing to the advancement of pharmaceutical research and drug discovery.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(4-Fluoro-phenyl)-4-methyl-pyridine serves as a key intermediate for the synthesis of agrochemicals. Its incorporation into the development process of new pesticides can enhance the effectiveness and selectivity of these products, thereby improving agricultural practices and crop protection.
Used in Organic Synthesis:
2-(4-Fluoro-phenyl)-4-methyl-pyridine is utilized as a reagent in organic synthesis, particularly for the preparation of complex molecules and pharmaceutical intermediates. Its presence in these reactions can facilitate the creation of intricate molecular structures, which are essential in the synthesis of advanced chemical compounds and therapeutic agents.

InChI:InChI=1/C12H10FN/c1-9-6-7-14-12(8-9)10-2-4-11(13)5-3-10/h2-8H,1H3

Upstream product

• 4926-28-7 2-Bromo-4-picoline 
• 1765-93-1 4-fluoroboronic acid 
• 3678-62-4 2-chloro-4-picoline 

Downstream Products

• 222551-13-5 4-bromomethyl-2-(4-fluoro-phenyl)pyridine 
• 1245614-29-2 2-(4'-fluorophenyl)-4-(4-methylstyryl)pyridine 
• 1245614-30-5 F-ppy-4-CH=CHC₆H₄NMe₂ 
• 446301-94-6 2-[2-(4-fluorophenyl)pyridin-4-yl]-1-(pyridin-2-yl)ethanone 

Relevant articles and documents

The new iridium(III) pyridyltetrazolate complexes for blue phosphorescence

A series of new blue-phosphorescent iridium complexes containing phenypyridine (ppy) derivatives and pyridyltetrazole were synthesized and their photophysical and electroluminescent properties were investigated. In the complex, the phenyl moiety which is

Suzuki-Miyaura cross-coupling for efficient synthesis of aryl-substituted N-heteroarenes catalyzed by recyclable N-phenylpiperazine-Palladium(II) complex

Polystyrene supported N-phenylpiperazine-Pd(II) complex D was synthesized and characterized by various techniques, including Fourier transform infrared spectroscopy (FTIR), scanning electronmicroscopy (SEM), energy dispersive X-ray spectroscopy (EDX) and thermal analysis (TG-DTA). This heterogeneous Pd(II) complex showed high catalytic efficiency for the Suzuki-Miyaura coupling of arylboronic acids with aryl bromides, aryl chlorides to give the corresponding 2-arylpyridines and heteroarenes. The coupled products were formed in excellent yields at low catalyst loadings under mild reaction conditions. Further, this heterogeneous catalyst showed excellent recyclability and reused for four cycles with no significant decrease in its activity.

α-Halo carbonyls enable: Meta selective primary, secondary and tertiary C-H alkylations by ruthenium catalysis

A catalytic meta selective C-H alkylation of arenes is described using a wide range of α-halo carbonyls as coupling partners. Previously unreported primary alkylations with high meta selectivity have been enabled by this methodology whereas using straight chain alkyl halides affords ortho substituted products. Mechanistic analysis reveals an activation pathway whereby cyclometalation with a ruthenium(ii) complex activates the substrate molecule and is responsible for the meta selectivity observed. A distinct second activation of the coupling partner allows site selective reaction between both components.

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