- Dichloro-naphthoquinone as a non-classical inhibitor of the mycobacterial carbonic anhydrase Rv3588c
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The soluble mycobacterial carbonic anhydrases Rv3588c and Rv1284 belong to a different class of carbonic anhydrases than those found in humans, making them attractive drug targets by using the inherent differences in the folds of the different classes. By screening a natural product library, we identified naphthoquinone derivatives as a novel non-classical inhibitor scaffold of mycobacterial carbonic anhydrases that lack the sulfonamide/sulfamate group and thus did not affect human carbonic anhydrase II.
- Dallaston,Rajan,Chekaiban,Wibowo,Cross,Coster,Davis,Hofmann
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- Colorimetric sensing and anion recognition by Kalanchoe flower-like ligand and its transition metal complexes with polarized N-H interaction motifs
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Herein we report the selective sensing of fluoride ion with kalanchoe flower-like ligand, L ( 2?chloro?3?((3?dimethylamino)propylamino)naphthalene?1,4?dione) and it's metal (K1-Cu(II), K2-Co(II), K3-Zn(II)) complexes. The morphology and anion sensing prop
- Devendiran, M.,Kalaivani, R. A.,Kosiha, A.,Kumar, K. Krishna
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- Composition for Distructing Microalgae
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The present invention relates to a composition for destroying microalgae, more specifically, to a composition for destroying microalgae containing naphthoquinone compounds having a specific exchange group. The composition for destroying microalgae, according to the present invention, can prevent green tide and red tide by being processed in areas such as cultivation facilities for microalgae, areas in which the green tide or the red tide occur, or areas expected to occur the green tide or the red tide.
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Paragraph 0429-0432
(2017/09/05)
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- Electron Transfer in Linked Viologen-Quinone Molecules: Rate Constant Enhancement with Increased Chain Length
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We synthesized a homologous series of molecules (MVnn'Q) where a methylviologen (MV) and a aminochloronaphthoquinone (Q) are linked to each other via a flexible chain.Using the electron pulse radiolysis technique, we have measured time-resolved spectra and rate constants for intra- and intermolecular electron transfer between donor and acceptor site of the MVnn'Q molecules in water and in SDS micellar solution.For comparison, we also irradiated a solution containing a 1:1 mixture of methylviologen and aminochloronaphthoquinone and measured spectra and intermolecular ET reactions between the separated electron donor and acceptor molecules.The intramolecular electron transfer rate constants of all MVnn'Q molecules were surprisingly low both in water and in aqueous SDS micellar suspensions.The intramolecular rate constants measured in water increase with increasing number of intervening bonds, leading to the conclusion that electron transfer occurs by a through-space rather than through-bond mechanism.The intramolecular rate constants virtually lose their chain length dependence in SDS suspensions where because of an extended configuration of the micelled MVnn'Q molecules through-space interaction is not favored.
- Brun, A. M.,Hubig, S. M.,Rodgers, M. A. J.,Wade, W. H.
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p. 710 - 715
(2007/10/02)
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