- Synthesis, characterization and biological activity of new cyclization products of 3-(4-substituted benzylidene)-2H-pyrido[1,2-a]pyrimidine 2,4-(3H)-diones
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A method is presented for the synthesis of 4-(substituted phenyl)-3-(3-substituted phenyl)4H-spiro[isoxazole-5,3′-pyrido[1,2-a] pyrimidine]-2′,4′-dione (3), 3-(4-substituted phenyl)-3H- isoxazole[3, 4-d]pyrido[1,2-a]pyrimidin-4-(3aH)-one (4) and 3-(4-substituted phenyl) 3,3a-dihydropyrazolo[3,4-d]pyrido[1,2-a]pyrimidin-4-(2H)-one (5) which consists of the conversion of 2H-pyrido[1,2-a]pyrimidine-2,4(3H)-dione (1) to chalcones (2) and their 1,3-dipolar cycloaddition with appropriate aldoximes to give spiro compounds and heterocyclization using amines to yield isoxazolines and pyrazolines. All the compounds were screened for their antimicrobial and antitubercular activity.
- Bishnoi, Abha,Singh, Suruchi,Tiwari, Anil K,Srivastava, Krishna,Raghuvir, Ram,Tripathi, Chandrakant M
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p. 305 - 312
(2013/07/26)
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- Synthesis of novel and biologically potent heteropolycyclics containing bridge head nitrogen
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(Chemical Equation Presented) A facile one pot synthesis of 2,3,4,5-tetrahydropyrido [1,2-a] [1,3] diazepine-2,5-dione 2 and 3,4-dihydro-2H-pyrido [1,2-a] pyrimidine-2,4-dione 3 has been achieved. Condensation of 3 with o-aminobenzaldehydes produced the l
- Gupta, Poonam,Gupta, Shallu,Sachar, Anand,Sharma
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experimental part
p. 1188 - 1199
(2010/11/16)
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- Electro-organic reactions part 35. Efficient carbon-oxygen bond formation in the anodic coupling of pyridopyrimidine derivatives
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4-H-Pyrido[1,2-a]pyrimidine-2,4-diones (Chichibabin) derivatives, formed by condensation of 2-aminopyridines with substituted dialkylmalonates, are electroactive. In solution in CH2Cl2/CF3CO2H mixtures they are smoothly and selectively anodically coupled in high yield. The products are novel and unexpected; radical coupling at the C-3 and O-4 positions is involved and the proposed mechanism is analogous to that of oxidative phenolic coupling.
- Gullu, Mustafa,Razack, Liaquat A.,Utley, James H. P.,King, Ronald J.,Ray White
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p. 675 - 684
(2007/10/02)
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