Iodine mediated an efficient and greener thiocyanation of aminopyrimidines by a modification of the Kaufmann's reaction
A new, safe, and efficient methodology for the thiocyanation of some aminopyrimidine derivatives has been implemented. The thiocyanation reactions proceeded at room temperature with high yields and selectivity. This route is a less toxic alternative to other common thiocyanation techniques because it uses molecular iodine as a halogen source, which is less reactive and easier to handle than chlorine or bromine.
Rodríguez, Ricaurte,Camargo, Patricia,Sierra, César A.,Soto, Carlos Y.,Cobo, Justo,Nogueras, Manuel
2-OXO-THIAZOLE DERIVATIVES AS A2A INHIBITORS AND COMPOUNDS FOR USE IN THE TREATMENT OF CANCERS
The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof. The invention further relates to the use of the compounds of Formula (I) as A2A inhibitors. The invention also relates to the use of the compounds of Formula (I) for the treatment and/or prevention of cancer. The invention also relates to a process for manufacturing compounds of Formula (I).
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Page/Page column 81-82
(2018/10/25)
Studies in the heterocyclic series. XVIII. Utilization of 4-aminopyrimidine chemistry in 1,4,7,9-tetraazabenzo[b]phenothiazine synthesis
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Okafor
p. 1587 - 1592
(2007/10/02)
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