- CRYSTAL OF THIAZOLIDINEDIONE COMPOUND, AND PROCESS FOR PRODUCTION THEREOF
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Thiazolidinedione compound crystalline forms useful as a bulk material for the manufacture of a peroxisome proliferator-activated receptor (PPAR) γ activator or an anticancer pharmaceutical composition are provided, which are hydrate crystalline forms of
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Page/Page column 12
(2011/04/25)
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- CRYSTAL OF THIAZOLIDINEDIONE COMPOUND, AND PROCESS FOR PRODUCTION THEREOF
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Thiazolidinedione compound crystalline forms useful as a bulk material for the manufacture of a peroxisome proliferator-activated receptor (PPAR) γ activator or an anticancer pharmaceutical composition are provided, which are hydrate crystalline forms of
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Page/Page column 14
(2011/05/05)
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- Amine derivative compounds
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An amine compound of the formula (I): wherein R1 represents an optionally substituted carbamoyl group, etc., R2 represents a hydrogen atom, etc., R3 represents a C1-C10 alkyl group etc., W1, W2 and W3 are the same or different and each represent a single bond or a C1-C8 alkylene group, X, Y and Q represent a sulfur atom, etc., Z represents a =CH- group, etc., Ar represents a benzene ring, etc. and L represents a hydrogen atom, etc., or a pharmacologically acceptable salt thereof. These compounds are useful in the treatment and/or prophylaxis of diseases such as diabetes, hyperlipemia, arteriosclerosis, cancer, etc.
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- AMINE DERIVATIVES
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An amine derivative compound of the formula (I):wherein R1 represents an optionally substituted carbamoyl group, etc., R2 represents a hydrogen atom, etc., R3 represents a C1-C10 alkyl group etc., W1, W2 and W3 are the same or different and each represent a single bond or a C1-C8 alkylene group, X, Y and Q represent a sulfur atom, etc., Z represents a =CH- group, etc., Ar represents a benzene ring, etc. and L represents a hydrogen atom, etc. or a pharmacologically acceptable salt thereof is useful as a therapeutic and/or preventing agent for diabetes, hyperlipemia, arteriosclerosis, cancer, etc.
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Page 117 - 118
(2010/01/31)
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- Substituted fused heterocyclic compound
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Substituted fused heterocyclic compounds of the formula (I) and pharmacologically acceptable salts thereof: wherein R1is a group of the formula (II) or (III): R4is a substituted phenyl or a pyridyl which may have a substituent. R5is hydrogen or the like. R6is hydrogen, a C1-6alkyl group or the like. D is oxygen or sulfur. E is a CH group or nitrogen. R2is hydrogen or the like. R3is a 2,4-dioxothiazolidin-5-ylmethyl group or the like. A is a C1-6alkylene group. B is oxygen or sulfur. These compounds and salts are useful as the active ingredient of pharmaceutical compositions which can be used to treat patients because these compounds and salts have excellent insulin-resistance improving action, lipid-peroxide-production inhibitory action, 5-lipoxygenase inhibitory action and the like.
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