- 2-substituted benzylthio-5-(4,6-dimethyl pyrimidine-2-)thiomethyl-1,3,4-oxadiazole compound and application thereof
-
The invention relates to a 2-substituted benzylthio-5-(4,6-dimethyl pyrimidine-2-)thiomethyl-1,3,4-oxadiazole compound and an application thereof. The compound provided by the invention is easy to prepare, and the aftertreatment is convenient; and the obtained compound is used as a bactericide against gotryis cinerea, fusarium oxysporum, fungus colletorichum acutatum, strawberry anthracnose or colletotrichum gloeosporioides and shows relatively good bacteriostatic activity.
- -
-
Paragraph 0024
(2016/10/10)
-
- 4-phenyl-3-((4,6-dimethylpyrimidin-2-yl thio)methyl)-5-benzylthio triazole compounds and application thereof
-
The invention relates to 4-phenyl-3-((4,6-dimethylpyrimidin-2-yl thio)methyl)-5-benzylthio triazole compounds and an application thereof; in the compounds, compounds having nonsubstituted H in a benzene ring show a certain inhibitory activity on all tested strains; the compounds Ia (Rn=p-cyano), Ib (Rn=p-bromo) and Ic (Rn=p-chloro) have all the inhibition rates on colletrichum orbiculare of more than or equal to 50%, wherein the inhibition rate of Ic is 73.24%; the compounds Ia (Rn=p-cyano), Ib (Rn=p-bromo), Ic (Rn=p-chloro) and Ih (Rn=o-chloro) have all the inhibition rates on botrytis cinerea of more than or equal to 40%; the compounds Ia (Rn=p-cyano), Ib (Rn=p-bromo) and Ic (Rn=p-chloro) have all the inhibition rates on rhizoctonia solani of more than or equal to 50%, wherein the inhibition rate of Ic is 66.37%.
- -
-
Paragraph 0021
(2016/10/17)
-
- 2-substituted benzylthio-5-(4,6-dimethyl pyrimidine-2-)sulfur methyl-1,3,4-thiadiazole compound and application thereof
-
The invention relates to a 2-substituted benzylthio-5-(4,6-dimethyl pyrimidine-2-)sulfur methyl-1,3,4-thiadiazole compound and application thereof. The compound is simple in preparation method, after-treatment is convenient, and the obtained compound has obvious effects when applied as bactericide for botryis cinerea, fusarium oxysporum, fungus colletorichum acutatum, strawberry anthracnose and colletotrichum gloeosporioides.
- -
-
Paragraph 0022
(2016/10/17)
-
- Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study
-
Sirtuins are NAD+-dependent protein deacylases that cleave off acetyl but also other acyl groups from the ε-amino group of lysines in histones and other substrate proteins. Dysregulation of human Sirt2 (hSirt2) activity has been associated with the pathogenesis of cancer, inflammation, and neurodegeneration, which makes the modulation of hSirt2 activity a promising strategy for pharmaceutical intervention. The sirtuin rearranging ligands (SirReals) have recently been discovered by us as highly potent and isotype-selective hSirt2 inhibitors. Here, we present a well-defined structure-activity relationship study, which rationalizes the unique features of the SirReals and probes the limits of modifications on this scaffold regarding inhibitor potency. Moreover, we present a crystal structure of hSirt2 in complex with an optimized SirReal derivative that exhibits an improved in vitro activity. Lastly, we show cellular hyperacetylation of the hSirt2 targeted tubulin caused by our improved lead structure.
- Schiedel, Matthias,Rumpf, Tobias,Karaman, Berin,Lehotzky, Attila,Oláh, Judit,Gerhardt, Stefan,Ovádi, Judit,Sippl, Wolfgang,Einsle, Oliver,Jung, Manfred
-
p. 1599 - 1612
(2016/03/05)
-
- Carboxyl activation of 2-mercapto-4,6-dimethylpyrimidine through n-acyl-4,6-dimethylpyrimidine-2-thione: A chemical and spectrophotometric investigation
-
2-Mercapto-4,6-dimethylpyrimidine, as effective carboxyl activating group, has been successfully proved by converting it into respective acyl derivatives and the subsequent conversion to the amides and esters respectively using amines, amino alcohols and alcohols. The aminolysis and esterification were monitored chemically and spectrophotometrically. This paved way to establish that the above mercaptopyrimidine derivative is an efficient carboxyl activating group applicable in solid phase peptide synthesis.
- Rajan
-
p. 287 - 291
(2015/01/30)
-
- Three Ternary Rare Earth(III) Complexes Based on 3-[(4,6-Dimethyl-2-pyrimidinyl)thio]-propanoic Acid and 1,10-Phenanthroline: Synthesis, Crystal Structure and Antioxidant Activity
-
Three ternary rare earth [NdIII (1), SmIII (2) and YIII (3)] complexes based on 3-[(4,6-dimethyl-2-pyrimidinyl)thio]-propanoic acid (HL) and 1,10-phenanthroline (Phen) were synthesized and characterized by IR and UV/Vis spectroscopy, TGA, and single-crystal X-ray diffraction. The crystal structures showed that complexes 1-3 contain dinuclear rare earth units bridged by four propionate groups and are of general formula [REL3(Phen)]2·nH2O (for 1 and 2: n = 2; for 3: n = 0). All rare earth ions are nine-coordinate with distorted mono-capped square antiprismatic coordination polyhedra. Complex 1 crystallizes in the monoclinic system, space group P21/c with a = 16.241(7) ?, b = 16.095(7) ?, c = 19.169(6) ?, β = 121.48(2)°. Complex 2 crystallizes in the monoclinic system, space group P21/c with a = 16.187(5) ?, b = 16.045(4) ?, c = 19.001(4) ?, β = 120.956(18)°. Complex 3 crystallizes in the triclinic system, space group P1 with a = 11.390(6) ?, b = 13.636(6) ?, c = 15.958(7) ?, α = 72.310(17)°, β = 77.548(15)°, γ = 78.288(16)°. The antioxidant activity test shows that all complexes own higher antioxidant activity than free ligands.
- Chen, Xiao,Qu, Jian-Qiang
-
p. 1301 - 1306
(2015/06/30)
-
- (4,6-Dimethyl-2-sulfanylidenepyrimidin-1-ium) trichlorido(thiourea- κS)zinc(II)
-
The title compound, (C6H9N2S)[ZnCl 3{SC(NH2)2}], exists as a zincate where the zinc(II) centre is coordinated by three chloride ligands and a thiourea ligand to form the anion. The organic cation adopts the protonated 4,6-dimethyl-2- sulfanylidenepyrimidin-1-ium (L) form of 4,6-dimethylpyrimidine-2(1H)-thione. Two short N-H...Cl hydrogen bonds involving the pyrimidine H atoms and the [ZnCl3L]- anion form a crystallographically centrosymmetric dimeric unit consisting of two anions and two cations. The packing structure is completed by longer-range hydrogen bonds donated by the thiourea NH2 groups to chloride ligand hydrogen-bond acceptors.
- Fu, Wei-Wei,Chen, Man-Sheng,Liu, Yang,Zhang, Fu-Xing
-
p. 384 - 387
(2013/07/05)
-
- Nitrogen-containing heterocycles from metal β-diketonates
-
Factors determining the reaction of metal β-diketonates with hydrazine, in particular the nature of central metal ion and structure of β-diketonate ligand, are discussed. The possibility for the preparation of other heterocyclic compounds via reaction of metal acetylacetonates with phenylhydrazine, o-phenylenediamine, urea, and thiourea was studied.
- Svistunova,Shapkin,Nikolaeva,Apanasenko
-
experimental part
p. 756 - 761
(2011/08/06)
-
- Facile synthesis and systematic investigations of a series of novel bent-shaped two-photon absorption chromophores based on pyrimidine
-
The synthesis, structure, and single- and two-photon spectroscopic properties of a series of pyrimidinebased (bent-shaped) molecules are reported. All these stable heterocyclic compounds are fully characterized, and exhibit intense single- and two-photon excited fluorescence (SPEF and TPEF) over a wide spectral range from blue to red, with the spectral peak position of the SPEF being basically the same as that of the TPEF. The well-conjugated p-systems, observed from the crystalstructure, indicate the charge transfer feature of the ground state. Meanwhile, the theoretical and experimental studies indicate that the charge transfer from donor to acceptor is greatly enhanced in the excited states and the different substituted donor groups on the pyrimidine have a large effect on the optical and electrochemical properties. Based on typical structure data and comprehensive spectral data, the following structure-property relationships can be determined: for such bentshaped chromophores, the absorption and the fluorescence wavelength maximum of the SPEF and TPEF, and twophoton absorption cross sections show a similar trend with increasing electron- donating strength of the corresponding terminal group and the number of branches, while the average bond lengths of the p-linkage and HOMO-LUMO energy levels show an inverse trend. Experimental data and theoretical calculation provide a coherent picture. With these findings, bentshaped quadrupolar chromophores combining peak TPA cross sections (up to 2280 GM), broad TPA bands throughout the whole 700-900 nm range, and high fluorescence quantum yields could, thus, be obtained. Such compounds are of particular interest for TPEF microscopy, as well as optical data storage in the visible and NIR regions. A data recording experiment proved the potential application of these materials.
- Li, Lin,Tian, Yu-Peng,Yang, Jia-Xiang,Sun, Ping-Ping,Wu, Jie-Ying,Zhou, Hong-Ping,Zhang, Sheng-Yi,Jin, Bao-Kang,Xing, Xiao-Juan,Wang, Chuan-Kui,Li, Ming,Cheng, Guang-Hua,Tang, Huo-Hong,Huang, Wen-Hao,Tao, Xu-Tang,Jiang, Min-Hua
-
supporting information; experimental part
p. 668 - 680
(2011/06/20)
-
- Microwave-expedited one-pot, two-component, solvent-free synthesis of functionalized pyrimidines
-
The synthesis of a series of diversely substituted pyrimidines under solvent-free conditions in good yields is described. Under microwave irradiation, a variety of nucleophilic substrates containing the N?C?N unit with ?-dicarbonyl compounds, ethyl cyanoacetate, malononitrile, and chalcones was cyclized to give pyrimidines. A combinatorial type approach for a one-step synthesis has been developed where a ring-closing condensation is followed by spontaneous aromatization to afford 28 functionalized and aryl/alkyl substituted pyrimidines. CSIRO 2007.
- Goswami, Shyamaprosad,Jana, Subrata,Dey, Swapan,Kumar Adak, Avijit
-
p. 120 - 123
(2008/02/11)
-
- Synthesis of new triazolopyrimidines and substituted pyrimidines.
-
Hydrazinopyrimidine 3 was prepared and transformed into 4, 5 by the reaction with Ar-Cl and POCl3, respectively. Also 3 transformed into 6, 7 by the reaction with ArCHO and FeCl3 respectively. Compound 8 was prepared and transformed into 9, 10, 11 by the reaction with DDC, ethyl bromoacetate and Sodium ethoxide respectively.
- Ouf
-
p. 275 - 279
(2007/10/03)
-
- 1N-alkyl-N-arylpyrimidinamines and derivatives thereof
-
The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppression, Alzheimer's disease, gastrointestinal diseases, anorexia nervosa, drug and alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems. The novel compounds provided by this invention are those of formula: wherein R1, R3, R4, R5, Z, Y, V, X, X', J, K, L, and M are as defined herein.
- -
-
-
- Thione-Disulfide Interchange of some Heterocyclic Tautomeric Thiones and their Symmetrical Bisulfides
-
The UV/Vis spectroscopic properties of some symmetrical disulfides derived from potentially tautomeric thiones are investigated. Reversed thione-disulfide transformation is observed, and the influence of several factors including the nature of solvent, concentration, and UV irradiation, is studied. Possible implication of the tautomeric thiol form and the importance of this thione-disulfide redox system in biological aspects is suggested. A general scheme including monomer-dimer equilibrium, thione-thiol tautomeric equilibrium, and reversible thiol-disulfide redox behaviour is proposed in order to explain the factors affecting the overall thione-disulfide transformation.
- Stoyanov,Stoyanova,Antonov,Karagiannidis,Akrivos
-
p. 495 - 504
(2007/10/03)
-
- INTRODUCTION OF SELENIUM TO HETEROCYCLIC COMPOUNDS. PART V. SYNTHESIS PF 2-PYRIMIDINESELENONES FROM 2-PYRIMIDINETHIONES
-
The earlier described method of introduction of selenium to the five-membered heterocyclic ring was applied to synthesize the six-membered heterocyclic ring containing an exocyclic atom of selenium.Ten new derivatives of 2-pyrimidineselenone have been obtained from methylation products of appropriate derivatives of 2-pyrimidinethione treated with the HSe- ion.The structure of the obtained compounds has been confirmed by spectral data.The contribution of and bond vibrations in the IR spectrum is discussed.
- Korohoda, Maria Jolanta,Slomska, Elzbieta,Szczurek, Halina
-
p. 165 - 171
(2007/10/02)
-
- A C-13 nuclear magnetic resonance study of the pyrimidine synthesis by the reactions of 1,3-dicarbonyl compounds with amidines and ureas
-
The detailed mechanistic pathways are elucidated for the reactions of acetylacetone, methyl acetoacetate, and dimethyl malonate with a variety of amidines and ureas.In many cases the identification of a single intermediate allows the definition of the reaction path and identification of two steps.Intermediates characterized include ring-closed dihydroxytetrahydropyrimidines, dihydrohydroxypyrimidinones, open-chain enamides, and carbonyl addition compounds.
- Katritzky, Alan R.,Yousaf, Taher I.
-
p. 2087 - 2093
(2007/10/02)
-
- Asymmetric Hydrogenation Catalyzed by Rhodium Complex with a New Chiral Bisphosphine Derived from L-Threonine
-
A new chiral bisphosphine, (2R,3S)-1,2-bis(diphenylphosphino)-3-'Boc-aminobutane (RS-5), was prepared from L-threonine.Mesylation of 'Boc-L-threonine methyl ester (2) and subsequent reduction with sodium borohydride gave the alcohol (10), which was treated with potassium carbonate to afford a key intermediate, (2S,3S)-1-'Boc-3-methyl-2-aziridinemethanol (SS-7b).Mesylation of SS-7b, followed by treatment with sodium diphenylphosphide afforded the new chiral bisphosphine (RS-5).The structure of RS-5 was confirmed by the X-ray analysis of its crystalline CuCl complex (RS-12).The cationic rhodium (I) complexes prepared from RS-5 and RS-12 are efficient asymmetric hydrogenation catalysts for N-acyldehydroamino acids, giving (S))-N-acylamino acids in high optical yields (83-94percentee).
- Saito, Kunio,Saijo, Shigeyoshi,Kotera, Keishi,Date, Tadamasa
-
p. 1342 - 1350
(2007/10/02)
-
- Use of 2-pyrimidine thiol carbonates as acylating agents for amino or imino containing compounds
-
Thiolcarbonates represented by the formula, SPC1 Wherein R1 and R2 are individually a hydrogen atom or a methyl group, and R3 is a straight chain or branched chain saturated or unsaturated alkyl group having 1 to 5 carbon atoms or is a benzyl or benzhydryl group which may be nuclear substituted, are quite useful for protecting the amino or imino groups of amines, hydrazines, amino acids and peptides with groups of the formula EQU1 The thiolcarbonates can be easily produced by reacting an alkali metal salt of 2-mercaptopyrimidine with phosgene, and reacting the resulting thiolchloroformate with an alcohol (R3 OH), or by reacting a 2-mercaptopyrimidine with a halocarbonic acid ester.
- -
-
-
- Process for acylation of amino, imino and hydroxyl groups using pyrimidine derivatives
-
Pyrimidine derivatives represented by the formula, SPC1 Wherein R1 and R2 are individually a hydrogen atom or a methyl group, and R3 is a group formed by removing the carboxyl group from a carboxylic acid, are quite useful in acylating compounds having amino and/or imino and/or hydroxyl groups. The pyrimidine derivatives can easily be prepared by reacting a 2-mercapto-4- and/or 6-methyl-substituted or unsubstituted pyrimidine with a carboxylic acid or a reactive derivative thereof in an inert solvent.
- -
-
-
