223272-49-9Relevant articles and documents
INHIBITORS OF DIHYDROCERAMIDE DESATURASE FOR TREATING DISEASE
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Paragraph 00247; 00259, (2018/09/11)
Disclosed herein are dihydroceramide desaturase 1 (Des1) inhibitor compounds and compositions, which are useful in the treatment of diseases, such as metabolic, cardiovascular, fibrotic, autoimmune/chronic inflammatory diseases, cystic fibrosis, various cancers, neurodegenerative diseases, lipid storage disorders, and ischemia/reperfusion injury, where inhibition of Des1 is expected to be therapeutic to a patient. Methods of inhibition of Des1 activity in a human or animal subject are also provided.
Composition containing fluorescence-generating substrate
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, (2008/06/13)
A fluorescent dye-forming composition is provided that contains a fluorescence-generating substrate of formula (I): where R1 and R2 are each independently a hydrogen atom, or an electron-donating group selected from a lower alkyl gro
Anionic Micellar Effects on the Benzophenone-sensitized Photolysis of N-(1-Naphthoyl)-N-phenyl-O-benzoylhydroxylamine
Kaneko, Tsuyoshi,Kubo, Kanji,Sakurai, Tadamitsu
, p. 2757 - 2774 (2007/10/03)
Most important property of compartmentalized liquids such as micelles is that they have an ability to concentrate guest molecules into relatively small effective volumes and then to promote the re-encounter of such molecules. This property also makes mice
The Photolysis of N,O-Diacyl-N-phenylhydroxylamines
Sakurai, Tadamitsu,Yamamoto, Hirofumi,Yamada, Shuichi,Inoue, Hiroyasu
, p. 1174 - 1181 (2007/10/02)
The photochemical decomposition of the title compounds yielded the rearrangement products derived from 1,3- and 1,5-aroyloxyl migrations in addition to the fragmentation products typical of the aroyloxyl and amido radicals, while only 1,3-aroyloxyl migration was observed on thermolysis.The results of crossover experiments indicate an intramolecular rearrangement, probably involving homolysis of the N-O bond in the excited states.Triplet quenching studies demonstrate that the rearrangement and fragmentation proceed exclusively via the first excited singlet state.No formation of the rearrangement products on triplet sensitization was expl ained on the basis of the spin multiplicity effects on a radical-radical recombination process within a solvent cage.