223646-08-0

Basic information

• Product Name: 5-phenyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
• Synonyms: 5-phenyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
• CAS NO: 223646-08-0
• Molecular Formula: C₁₃H₁₀N₂O
• Molecular Weight: 210.2313
• Mol File: 223646-08-0.mol

Chemical Properties

• Boiling Point: 387.0±52.0 °C(Predicted)
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.20±0.20(Predicted)
• CAS DataBase Reference: 5-phenyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-phenyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one(223646-08-0)
• EPA Substance Registry System: 5-phenyl-1H-pyrrolo[2,3-b]pyridin-2(3H)-one(223646-08-0)

Safety Data

• Hazardous Substances Data: 223646-08-0(Hazardous Substances Data)

Upstream product

• 183208-34-6 5-bromo-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one 
• 98-80-6 phenylboronic acid 

Downstream Products

• 295327-30-9 3-[Ethoxymethylidene]-5-phenyl-1H-pyrrolo[2,3-b]pyridin-2-one 
• 297757-18-7 3-ethoxymethylene-5-phenyl-7-azaoxindole 

Relevant articles and documents

Molybdenum hexacarbonyl mediated synthesis of indolin-2-one & azaindolin-2-one under catalyst free conditions

Syntheses of indolin-2-ones and azaindolin-2-ones have been realized. The strategy involves the formation of tosylhydrazone from tosylhydrazine and 2-amino aryl or pyridyl aldehydes/ketones which then undergo intramolecular aminocarbonylation to afford indolin-2-ones and azaindolin-2-ones. The generality of the method was demonstrated by synthesizing C3 substituted and unsubstituted indolin-2-one and azaindolin-2-one derivatives.

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Synthesis of 5-Substituted 7-Azaoxindoles via Palladium-Catalyzed Reactions

A synthesis of 5-substituted 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-ones (5-substituted 7-azaoxindoles) via palladium-catalyzed Suzuki coupling, Stille coupling, and carbonylation reactions is described.