- A SIMPLE METHOD FOR THE SYNTHESIS OF SOME 1,2-DIAZOCINES
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Cyclobutanone reacts with diphenyl-1,2,4,5-tetrazine, in alcoholic base and in diethylamine, to give 3,8-diphenyl-6,7-dihydro-1,2-diazocin-4(5H)-one (5) and 4-diethylamino-3,8-diphenyl-6,7-dihydro-1,2-diazocine (8) respectively.With diethylamine the tetra
- Haddadin, Makhluf J.,Agha, Bushra J.,Salka, M. Samer
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p. 2577 - 2580
(2007/10/02)
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- The Role of Lithium Amides as Reducing Agents in a Novel Pathway to 3,6-Diarylpyridazines by Ring Transformations of 3,6-Diaryl-s-tetrazines
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3,6-Diaryl-s-tetrazines undergo two competing reactions when treated with lithium amides.The first, direct nucleophilic attack and addition of lithium amide to the tetrazine, appears to be predominant when a less hindered amide is used, and moderate quantities of tetrazine are then regenerated on quenching.The competing reaction, which is seen more clearly with a bulkier amide such as lithium di-isopropylamide, involves reduction of tetrazine to a dihydro derivative with concomitant formation of imine from the amide: this imine is then attacked by further amide and gives rise to a charged intermediate which reacts with more tetrazine to form a pyridazine.
- Hunter, Daniel,Neilson, Douglas G.
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p. 1601 - 1603
(2007/10/02)
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