- General method for determination of configuration of steroid-17-yL methyl glycolates at C-20
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Kinetic examination for methoxycarbonylations of the isomeric steroid-17- yl methyl glycolates at C-20 and plots of the amount of each isomer produced by a reaction of their corresponding steroids with cupric acetate in absolute methanol provide a general and facile method for determination of the configuration of the steroid-17-yl methyl glycolates at C-20.
- Suzuki,Tada,Matsuda,Yang,Unno
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p. 1481 - 1483
(2007/10/02)
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- Novel pregnane-21-oic acid derivatives
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Pregnane-21-oic acids of the formula SPC1 Wherein X is a hydrogen atom, a fluorine atom, or methyl; Y is a hydrogen atom, a fluorine atom, or a chlorine atom; Z is methylene, carbonyl, β-hydroxymethylene, β-acyloxymethylene or when Y is a chlorine atom, β-fluoromethylene or β-chloromethylene; V is methylene, ethylidene or vinylidene; R1 is a hydrogen atom or acyl, and physiologically acceptable salts thereof with bases and physiologically acceptable 21-esters thereof, possess topical anti-inflammatory activity with substantially no systemic activity.
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