225641-94-1

Basic information

• Product Name: 3,4-Difluorophenylglycine
• Synonyms: Benzeneacetic acid, alpha-aMino-3,4-difluoro-;2-(3,4-Difluorophenyl)glycine;3,4-Difluoro-DL-phenylglycine 98%;Amino(3,4-difluorophenyl)acetic acid, 2-Amino-2-(3,4-difluorophenyl)ethanoic acid;3,4-Difluoro-DL-phenylglycine98%;3,4-Difluorophenylglycine98%
• CAS NO: 225641-94-1
• Molecular Formula: C8H7F2NO2
• Molecular Weight: 187.15
• Mol File: 225641-94-1.mol

Chemical Properties

• Boiling Point: 289 °C at 760 mmHg
• Flash Point: 128.6 °C
• Appearance: /
• Density: 1.442 g/cm³
• Vapor Pressure: 0.00104mmHg at 25°C
• Refractive Index: 1.543
• PKA: 1.70±0.10(Predicted)
• CAS DataBase Reference: 3,4-Difluorophenylglycine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Difluorophenylglycine(225641-94-1)
• EPA Substance Registry System: 3,4-Difluorophenylglycine(225641-94-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 225641-94-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3,4-Difluorophenylglycine is used as a key intermediate in the synthesis of pharmaceuticals for the treatment of neurological disorders. Its incorporation into drug molecules can enhance their bioavailability and metabolic stability, making it a promising candidate for drug development.
Used in Agrochemical Industry:
3,4-Difluorophenylglycine is utilized in the production of agrochemicals, such as pesticides and herbicides. Its unique chemical properties allow for the development of more effective and targeted agrochemicals, contributing to improved crop protection and yield.
Used in Specialty Chemicals Production:
3,4-Difluorophenylglycine serves as a building block in the synthesis of specialty chemicals, which have a wide range of applications in various industries, including materials science, coatings, and polymers. Its reactivity and properties enable the creation of novel compounds with specific characteristics, catering to the needs of different applications.

InChI:InChI=1/C8H7F2NO2/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7H,11H2,(H,12,13)

Upstream product

• 218449-30-0 amino-(3,4-difluorophenyl)-acetonitrile 

Relevant articles and documents

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Optimization of high-throughput screening hit 1a led to the identification of a novel spiro-piperidine class of melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. Compound 3c was identified as a highly potent and selective MCH-1R antagonist, which has an IC50 value of 0.09 nM at hMCH-1R. The synthesis and structure-activity relationships of the novel spiro-piperidine MCH-1R antagonists are described.