- A Practical and Chemoselective Ammonia-Free Birch Reduction
-
A novel protocol for a significantly improved, practical, and chemoselective ammonia-free Birch reduction mediated by bench-stable sodium dispersions and recoverable 15-crown-5 ether is reported. A broad range of aromatic and heteroaromatic compounds is reduced with excellent yields.
- Lei, Peng,Ding, Yuxuan,Zhang, Xiaohe,Adijiang, Adila,Li, Hengzhao,Ling, Yun,An, Jie
-
-
Read Online
- Birch Reduction of Arenes Using Sodium Dispersion and DMI under Mild Conditions
-
An easy-to-handle sodium dispersion in paraffin oil (SD), in combination with inexpensive and environmentally benign 1,3- dimethyl-2-imidazolidinone (DMI) as an additive enables the Birch-type reduction of a variety of arenes with high yields, selectivity, and tolerance of functionality such as ether, alcohol, amine, amide, and carboxylic acid.
- Asako, Sobi,Ilies, Laurean,Kurogi, Takashi,Murakami, Yoshiaki,Takahashi, Ikko,Takai, Kazuhiko
-
supporting information
p. 38 - 40
(2022/01/12)
-
- Reduction method of electronic salt reaction liquid and unsaturated aromatic hydrocarbon compound
-
To the reduction method, tetrahydrofuran is used as a solvent and an electron trapping agent, metal lithium is used as a reducing agent, tertiary butanol is used as a reducing agent, and the unsaturated aromatic hydrocarbon compound is reduced under -10 - 0 °C conditions. The raw material tetrahydrofuran is used in the invention. Metal lithium and tert-butyl alcohol are all conventional chemical products, and are simple and easy to obtain. After the reaction is finished, excess lithium and solvent are recovered, and directly used to realize low cost, low pollution and high yield.
- -
-
Paragraph 0076-0079
(2021/11/10)
-
- Novel electronic salt system and method for reducing unsaturated hydrocarbon compound
-
The invention discloses an electronic salt system and a method for reducing unsaturated hydrocarbon compounds by using the electronic salt system, belongs to the field of organic synthesis, and solvesthe problems such as complicated operation, harsh conditions, easy generation of complex over-reduction products of methods for reducing the unsaturated hydrocarbon compounds in the prior art. An electron salt may be synthesized by an alkali metal reagent, an ether and an alcohol, the ether can be a crown ether or a cryptand; and the method adopts the electronic salt system, the unsaturated hydrocarbon compounds is reduced by the electronic salt system in an organic solvent. The method for reducing the unsaturated hydrocarbon compounds is used for reducing the unsaturated hydrocarbon compounds.
- -
-
Paragraph 0102-0106
(2018/09/08)
-