22601-71-4

Basic information

• Product Name: L-Asn-L-Leu-OH
• Synonyms: L-Asn-L-Leu-OH;N-L-Asparaginyl-L-leucine
• CAS NO: 22601-71-4
• Molecular Formula: C10H19N3O4
• Molecular Weight: 0
• Mol File: 22601-71-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: L-Asn-L-Leu-OH(CAS DataBase Reference)
• NIST Chemistry Reference: L-Asn-L-Leu-OH(22601-71-4)
• EPA Substance Registry System: L-Asn-L-Leu-OH(22601-71-4)

Safety Data

• Hazardous Substances Data: 22601-71-4(Hazardous Substances Data)

Upstream product

• 106409-04-5 N-(N²-trityl-L-asparaginyl)-L-leucine 
• 20806-11-5 N-(p-Methoxy-benzyloxycarbonyl)-L-asparagyl-<β-bis-(2,4-dimethoxy-benzyl)-amid>-L-leucin-methylester 
• 61-90-5 L-leucine 
• 70-47-3 L-asparagine 
• 2462-35-3 L-leucine benzyl ester hydrochloride 

Relevant articles and documents

Identification of novel L-amino acid α-ligases through hidden markov model-based profile analysis

L-Amino acid α-ligase (Lal), catalyzing the formation of α-dipeptides from unprotected l-amino acids in an ATP-dependent manner, is used in cost-effective fermentative production of dipeptides. We searched for novel Lals by in silico screening using Hidden Markov Model-based profile analysis, and identified five novel Lals that showed low similarity and different substrate specificity from known Lals.

DPP4 INHIBITOR AND PHARMACEUTICAL APPLICATION THEREOF

The present invention provides a Dpp4 inhibitor which comprises a leucine derivative of the following formula (1) or a methionine derivative of the following formula (2): wherein each R1 and R3 represents a hydrogen atom (H) and an L-amino acid residue; R2 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline, alanine and phenylalanine) residue or L-amino-acid amide (except for proline amide, alanine amide and phenylalanine amide) residue; and R4 represents a hydroxyl group (OH), alkoxy group having 1 to 6 carbon atoms, amino group (NH2), alkylamino group having 1 to 6 carbon atoms, glycine residue, β-alanine residue, L-amino acid (except for proline and alanine) residue or L-amino-acid amide (except for proline amide and alanine amide) residue. These derivatives also act as autophagy regulators.