226419-21-2

Basic information

• Product Name: 4-Chloro-3,5-dimethoxyaniline
• Synonyms: 4-Chloro-3,5-dimethoxyaniline
• CAS NO: 226419-21-2
• Molecular Formula: C₈H₁₀ClNO₂
• Molecular Weight: 187.6235
• Mol File: 226419-21-2.mol

Chemical Properties

• Boiling Point: 324.6±37.0 °C(Predicted)
• Appearance: /
• Density: 1.237±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.11±0.10(Predicted)
• CAS DataBase Reference: 4-Chloro-3,5-dimethoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-3,5-dimethoxyaniline(226419-21-2)
• EPA Substance Registry System: 4-Chloro-3,5-dimethoxyaniline(226419-21-2)

Safety Data

• Hazardous Substances Data: 226419-21-2(Hazardous Substances Data)

Upstream product

• 10272-07-8 3.5-dimethoxyaniline 

Downstream Products

• 1272528-60-5 2-chloro-5-iodo-1,3-dimethoxybenzene 
• 1272528-62-7 2-chloro-5-iodobenzene-1,3-diol 
• 1272528-64-9 2-chloro-5-iodo-1,3-phenylene diacetate 
• 1272528-66-1 2-chloro-3-hydroxy-5-iodophenyl acetate 
• 1272528-67-2 2-chloro-3-ethoxy-5-iodophenol 
• 56518-51-5 ethyl 4-chloro-3,5-dimethoxybenzoate 
• 102338-87-4 4-chloro-3,5-dihydroxybenzoic acid 
• 1272528-73-0 2-chloro-5-iodo-3-methoxyphenol 
• 1610450-75-3 4-chloro-3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)aniline 
• 1610450-74-2 5-amino-2-chloro-3-methoxyphenol 
• 78025-93-1 3,5-dimethoxy-4-methylaniline 

Relevant articles and documents

Btk INHIBITORS WITH IMPROVED DUAL SELECTIVITY

Disclosed herein is a tri-substituted phenyl Btk inhibitors with improved dual selectivity, a method and a composition for inhibiting Btk and treating disease associated with undesirable Btk activity (Btk-related diseases).

Copper-Mediated monochlorination of anilines and nitrogen-containing heterocycles

A simple and selective copper(II) chloride-mediated monochlorination of anilines and nitrogen-containing heterocycles has been developed. Stirring a mixture of aniline, copper(II) chloride, lithium chloride in EtOH under reflux condition produced 4-chloroaniline with high yield. Eighteen substrates including substituted anilines, N-substituted anilines, N,N-disubstituted anilines, 5-nitroindole and carbazole were all reactive and afforded desired products in moderate to excellent yields (52%–98%).

Isolation, Synthesis, and Biological Activity of Chlorinated Alkylresorcinols from Dictyostelium Cellular Slime Molds

Eight chlorinated alkylresorcinols, monochasiol A-H (1-8), were isolated from the fruiting bodies of Dictyostelium monochasioides. Compounds 1-8 were synthesized to confirm their structures and to obtain sufficient material for performing biological tests. Monochasiol A (1) selectively inhibited the concanavalin A-induced interleukin-2 production in Jurkat cells, a human T lymphocyte cell line. Monochasiols were biogenetically synthesized by the combination of biosynthetic enzymes relating to the principal polyketides, MPBD and DIF-1, produced by Dictyostelium discoideum.

BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS

Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.

POTENT DUAL BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS

Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects, disclosed are compounds of Formula I-IV.

Therapeutic Aryl-Amido-Aryl Compounds and Their Use

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively referred to herein as “AAA compounds”), which, inter alia, a

THERAPEUTIC ARYL-AM I DO-ARYL COMPOUNDS AND THEIR USE

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively referred to herein as "AAA compounds"), which, inter alia, a